Department of Medicine, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Department of Family, Community Medicine, & Medical Education, College of Medicine, Taibah University, Madinah, Saudi Arabia.
JMIR Dermatol. 2024 Jul 12;7:e60686. doi: 10.2196/60686.
BACKGROUND: Vitiligo, a common dermatological disorder in Saudi Arabia, is associated with significant psychological impacts. This study explores the relationship between vitiligo and the severity of major depressive disorder (MDD), highlighting the broader implications on mental health among affected individuals. OBJECTIVE: We aim to assess the prevalence and predictors of depression among adult patients with vitiligo, and to examine the relationship between MDD severity and vitiligo. METHODS: Using a cross-sectional design, the research used the vitiligo area severity index and the Patient Health Questionnaire-9 to measure the extent of vitiligo and depression severity, respectively. This study involved 340 diagnosed patients with vitiligo from various health care settings. Logistic and ordinal regression analysis were applied to evaluate the impact of sociodemographic variables and vitiligo types on MDD severity. RESULTS: The prevalence of MDD was 58.8% (200/340) of participants. Depression severity varied notably: 18.2% (62/340) of patients experienced mild depression, 17.9% (61/340) moderate, 11.8% (40/340) moderately severe, and 10.9% (37/340) severe depression. Female patients had higher odds of severe depression than male patients (adjusted odds ratio [aOR] 3.14, 95% CI 1.93-5.1; P<.001). Age was inversely related to depression severity, with patients aged older than 60 years showing significantly lower odds (aOR 0.1, 95% CI 0.03-0.39; P<.001). Lower income was associated with higher depression severity (aOR 10.2, 95% CI 3.25-31.8; P<.001). Vitiligo types also influenced depression severity; vulgaris (aOR 5.3, 95% CI 2.6-10.9; P<.001) and acrofacial vitiligo (aOR 2.8, 95% CI 1.5-5.1; P<.001) were significantly associated with higher depression levels compared to focal vitiligo. CONCLUSIONS: The findings suggest that vitiligo contributes to an increased risk of severe depression, highlighting the need for integrated dermatological and psychological treatment approaches to address both the physical and mental health aspects of the disease.
背景：白癜风是沙特阿拉伯常见的皮肤病，与显著的心理影响相关。本研究探讨了白癜风与重度抑郁症（MDD）严重程度之间的关系，强调了该病对受影响个体心理健康的更广泛影响。
目的：我们旨在评估成年白癜风患者中抑郁的患病率和预测因素，并检查 MDD 严重程度与白癜风之间的关系。
方法：采用横断面设计，研究使用白癜风面积严重指数和患者健康问卷-9 分别衡量白癜风的严重程度和抑郁严重程度。该研究纳入了来自不同医疗保健环境的 340 名确诊白癜风患者。应用逻辑回归和有序回归分析评估社会人口学变量和白癜风类型对 MDD 严重程度的影响。
结果：MDD 的患病率为 58.8%（200/340）。抑郁严重程度差异显著：18.2%（62/340）的患者为轻度抑郁，17.9%（61/340）为中度，11.8%（40/340）为中度重度，10.9%（37/340）为重度抑郁。女性患者患重度抑郁的可能性高于男性患者（调整优势比[OR]3.14，95%CI1.93-5.1；P<.001）。年龄与抑郁严重程度呈负相关，年龄大于 60 岁的患者抑郁严重程度显著降低（调整 OR0.1，95%CI0.03-0.39；P<.001）。较低的收入与较高的抑郁严重程度相关（调整 OR10.2，95%CI3.25-31.8；P<.001）。白癜风类型也影响抑郁严重程度；泛发性（调整 OR5.3，95%CI2.6-10.9；P<.001）和肢端性白癜风（调整 OR2.8，95%CI1.5-5.1；P<.001）与局限性白癜风相比，抑郁水平显著升高。
结论：研究结果表明，白癜风会增加重度抑郁的风险，突出表明需要综合皮肤病学和心理学治疗方法来解决疾病的身体和心理健康方面。
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