Bonen A, Ness G W, Belcastro A N, Kirby R L
J Appl Physiol (1985). 1985 May;58(5):1622-9. doi: 10.1152/jappl.1985.58.5.1622.
Bicycle ergometric exercise was used to deplete glycogen by either 80 or 35% in the vastus lateralis of both legs. Thereafter, subjects from each group rested or maintained single-leg exercise [20% of maximal O2 consumption (Vo2max) for 4 h. All subjects ingested glucose (1.5 g/kg wt; 20% solution) at min 10-12 and min 130-132 of the 4-h period. With bed rest, significant glycogen increases occurred after exhaustive (+36%; P less than 0.05) and nonexhaustive exercise (+13%; P less than 0.05). With single-leg exercise, 1) a diminished glycogen repletion occurred in exercising (+11%; P less than 0.05) and nonexercising (+15%; P less than 0.05) muscle after exhaustive exercise, or 2) further glycogen loss occurred in exercising (-26%; P less than 0.05) and nonexercising muscle (-19%; P less than 0.05) after nonexhaustive exercise. Within both groups, glycogen concentrations did not differ between exercising and nonexercising muscles (P greater than 0.05). Single-leg exercise, not preceded by exercise, provoked differences in glycogen loss in exercising (-47%) and nonexercising (-24%) muscle (P less than 0.05). These experiments demonstrate that mild exercise 1) impedes glycogen resynthesis or 2) provokes glycogen loss in both exercising and nonexercising muscle. These findings cannot be ascribed to circulating glucose and insulin concentrations in these studies.
采用自行车测力运动使双腿股外侧肌糖原消耗80%或35%。此后，每组受试者休息或进行单腿运动[最大耗氧量（Vo2max）的20%，持续4小时]。所有受试者在4小时时间段的第10 - 12分钟和第130 - 132分钟摄入葡萄糖（1.5 g/kg体重；20%溶液）。卧床休息时，力竭运动后糖原显著增加（+36%；P<0.05），非力竭运动后糖原也显著增加（+13%；P<0.05）。进行单腿运动时，1）力竭运动后，运动肌肉（+11%；P<0.05）和非运动肌肉（+15%；P<0.05）的糖原再合成减少，或者2）非力竭运动后，运动肌肉（-26%；P<0.05）和非运动肌肉（-19%；P<0.05）的糖原进一步流失。在两组中，运动肌肉和非运动肌肉的糖原浓度无差异（P>0.05）。未进行运动前的单腿运动导致运动肌肉（-47%）和非运动肌肉（-24%）的糖原流失存在差异（P<0.05）。这些实验表明，轻度运动1）会阻碍糖原再合成，或2）会导致运动肌肉和非运动肌肉的糖原流失。在这些研究中，这些发现不能归因于循环中的葡萄糖和胰岛素浓度。
