Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA.
Obstetrics and Gynecology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA
BMJ Case Rep. 2024 Jun 18;17(6):e258188. doi: 10.1136/bcr-2023-258188.
Eclampsia spectrum disorders are a set of serious complications of pregnancy that commonly present after 20 weeks of gestation. There is an association between molar pregnancy, a gestational trophoblastic disease resulting from abnormal fertilisation and gametogenesis, and eclampsia spectrum disorders which can result in manifestation of pre-eclamptic symptomatology earlier than 20 weeks of gestation. We report a case of a gravida 1 para 0 in her mid 20s at 16-weeks gestation presenting with partial hydatidiform mole who developed eclampsia, haemolysis, elevated liver enzymes and low platelets syndrome and posterior reversible encephalopathy syndrome. Ultrasound findings were consistent with molar pregnancy and pathology confirmed partial molar pregnancy with triploid 69, XYY karyotype. This case highlights the early onset potential of eclampsia spectrum disorders in molar pregnancies while suggesting screening such patients for hypertensive disorders.
子痫前期谱疾病是一组严重的妊娠并发症，通常在妊娠 20 周后出现。葡萄胎，一种由于受精和配子发生异常导致的妊娠滋养细胞疾病，与子痫前期谱疾病之间存在关联，可能导致子痫前期症状在 20 周前出现。我们报告了一例 20 多岁的初产妇，妊娠 16 周时出现部分性葡萄胎，发生子痫、溶血、肝酶升高和血小板减少综合征和可逆性后部脑病综合征。超声检查结果与葡萄胎一致，病理检查证实为部分性葡萄胎，核型为三倍体 69，XYY。本例提示葡萄胎中子痫前期谱疾病的发病可能较早，同时建议对这类患者进行高血压疾病的筛查。
