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基于群组轨迹建模的中性粒细胞与淋巴细胞比值与空腹血糖受损关系的随访研究。

Follow-up study to explore the relationship between Neutrophil to lymphocyte ratio and impaired fasting glucose-using the group-based trajectory modeling.

机构信息

Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Medical University Affiliated Xuzhou Clinical Collage, Xuzhou, Jiangsu, China.

Xuzhou Medical University, Xuzhou, Jiangsu, China.

出版信息

Sci Rep. 2024 Jun 18;14(1):14064. doi: 10.1038/s41598-024-64701-5.

DOI:10.1038/s41598-024-64701-5
PMID:38890369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11189411/
Abstract

Previous studies have indicated a link between neutrophil to lymphocyte ratio (NLR) and impaired fasting glucose (IFG), but the findings have been disputed. By conducting a real-world follow-up study, we can monitor the development of diseases and confirm the connection between NLR and IFG. A total of 1168 patients without IFG or T2DM were followed up for six years. At baseline, participants' NLR levels, fasting plasma glucose and other clinical characteristics were recorded. During the follow-up period, NLR levels and the prevalence of IFG were recorded. Ultimately, 45 individuals were lost to follow-up, leaving 1,123 participants for analysis. Using Group-Based Trajectory Modeling (GBTM), the sample was divided into three groups. The prevalence of IFG in the three groups was 12.1%, 19.4%, and 20.85%, respectively. Compared with the low-level NLR group, the hazard ratio of IFG in the moderate-level NLR group and high-level NLR group were 1.628 (1.109-2.390) and 1.575 (1.001-2.497), respectively. There was a significant interaction effect of BMI and NLR on the risk of IFG (P < 0.001). In this real-world follow-up study, we observed a positive association between NLR and the risk of IFG, with this relationship being exacerbated by obesity status.

摘要

先前的研究表明中性粒细胞与淋巴细胞比值（NLR）与空腹血糖受损（IFG）之间存在关联，但研究结果存在争议。通过进行真实世界的随访研究，我们可以监测疾病的发展并确认 NLR 与 IFG 之间的联系。共对 1168 例无 IFG 或 T2DM 的患者进行了六年的随访。在基线时，记录了参与者的 NLR 水平、空腹血糖和其他临床特征。在随访期间，记录了 NLR 水平和 IFG 的患病率。最终，有 45 人失访，1123 人被纳入分析。使用基于群组的轨迹建模（GBTM），将样本分为三组。三组的 IFG 患病率分别为 12.1%、19.4%和 20.85%。与 NLR 低水平组相比，NLR 中水平组和高水平组发生 IFG 的危险比分别为 1.628（1.109-2.390）和 1.575（1.001-2.497）。BMI 和 NLR 对 IFG 风险的交互作用有显著影响（P<0.001）。在这项真实世界的随访研究中，我们观察到 NLR 与 IFG 风险之间存在正相关关系，且这种关系在肥胖状态下更为明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/5cdcd8d1687e/41598_2024_64701_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/58975cbf93e7/41598_2024_64701_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/00448a9d76d1/41598_2024_64701_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/5415c618647c/41598_2024_64701_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/5cdcd8d1687e/41598_2024_64701_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/58975cbf93e7/41598_2024_64701_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/00448a9d76d1/41598_2024_64701_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/5415c618647c/41598_2024_64701_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f6/11189411/5cdcd8d1687e/41598_2024_64701_Fig4_HTML.jpg

相似文献

[1]
Follow-up study to explore the relationship between Neutrophil to lymphocyte ratio and impaired fasting glucose-using the group-based trajectory modeling.

Sci Rep. 2024-6-18

[2]
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Metab Syndr Relat Disord. 2021-3

[3]
[Situation of impaired glucose regulation and metabolic syndrome in overweight or obesity adolescent students in Dongguan city].

Zhonghua Yu Fang Yi Xue Za Zhi. 2009-6

[4]
Risk of chronic kidney disease in young adults with impaired glucose tolerance/impaired fasting glucose: a retrospective cohort study using electronic primary care records.

BMC Nephrol. 2018-2-26

[5]
Six-year follow-up study on the association between white blood cell count and fasting blood glucose level in Chinese adults: A community-based health examination survey.

Diabetes Metab Res Rev. 2019-2-6

[6]
The characteristics of impaired fasting glucose associated with obesity and dyslipidaemia in a Chinese population.

BMC Public Health. 2010-3-17

[7]
Impaired fasting glucose and impaired glucose tolerance do not predict hypertension: a community cohort study.

Am J Hypertens. 2015-4

[8]
Does elevated plasma triglyceride level independently predict impaired fasting glucose?: the Multi-Ethnic Study of Atherosclerosis (MESA).

Diabetes Care. 2012-10-1

[9]
Determinants of progression from impaired fasting glucose and impaired glucose tolerance to diabetes in a high-risk screened population: 3 year follow-up in the ADDITION study, Denmark.

Diabetologia. 2008-2

[10]
Natural history of insulin sensitivity and insulin secretion in the progression from normal glucose tolerance to impaired fasting glycemia and impaired glucose tolerance: the Inter99 study.

Diabetes Care. 2009-3

本文引用的文献

[1]
Geriatric nutritional risk index as a predictor for fragility fracture risk in elderly with type 2 diabetes mellitus: A 9-year ambispective longitudinal cohort study.

Clin Nutr. 2024-5

[2]
Insulin resistance, combined with health-related lifestyles, psychological traits and adverse cardiometabolic profiles, is associated with cardiovascular diseases: findings from the BHMC study.

Food Funct. 2024-4-2

[3]
The Ratio of Red Blood Cell Distribution Width to Albumin as a Predictor for Rehospitalization Risk and Rehospitalization All-Cause Mortality in Middle-Aged and Elderly Survivors with Sepsis: An Ambispective ICU Cohort Study.

J Inflamm Res. 2024-2-22

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The neutrophil-to-lymphocyte ratio as a new prognostic factor in cancers: a narrative review.

Front Oncol. 2023-10-4

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Nat Immunol. 2023-5

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Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio and Their Dynamic Changes with Type 2 Diabetes Mellitus: A Cohort Study in China.

Endocr Res. 2022

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Leukocytes and Neutrophil-Lymphocyte Ratio as Indicators of Insulin Resistance in Overweight/Obese School-Children.

Front Nutr. 2022-5-6

[10]
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Inflamm Regen. 2022-5-1

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