Rivero-Salgado Gloria Manuela, Zamudio Sergio Roberto, Fregoso-Aguilar Tomás Alejandro, Quevedo-Corona Lucía
Departamento de Fisiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Av. Wilfrido Massieu 399, Nueva Industrial Vallejo, Gustavo A. Madero, Mexico City 07738, Mexico.
Foods. 2024 May 30;13(11):1720. doi: 10.3390/foods13111720.
Obesity is a global health problem and is increasing in prevalence in most countries. Although obesity affects all age groups, children are the most vulnerable sector. Functional foods are novel formulated foods containing substances (i.e., nutrients, phytochemicals, probiotics, etc.) that have potential health-enhancing or disease-preventing value. The research objective was to study the possible beneficial effects of providing a functional food made with amaranth flour, chia seed, and curcumin extract on the metabolism and behavior of a rat model of childhood obesity. Male Wistar rat pups from two litters of different sizes, a normal litter (NL) (10 pups) and a small litter (SL) (4 pups), were used. After weaning, the rats were fed a hypercaloric diet (HD) or an HD supplemented with the functional food mixture. Body weight and energy intake were measured for seven weeks, and locomotor activity, learning, and memory tests were also performed. At the end of the experiment, glucose and lipid metabolism parameters were determined. The results showed that in this model of obesity produced by early overfeeding and the consumption of a hypercaloric diet, anxiety-like behaviors and metabolic alterations occurred in the rat offspring; however, the provision of the functional food failed to reduce or prevent these alterations, and an exacerbation was even observed in some metabolic indicators. Interestingly, in the NL rats, the provision of the functional food produced some of the expected improvements in health, such as significant decreases in body weight gain and liver cholesterol and non-significant decreases in adipose tissue and leptin and insulin serum levels.
肥胖是一个全球性的健康问题，在大多数国家的患病率都在上升。尽管肥胖影响所有年龄组，但儿童是最脆弱的群体。功能性食品是新型配方食品，含有具有潜在增进健康或预防疾病价值的物质（即营养素、植物化学物质、益生菌等）。本研究的目的是探讨用苋菜籽粉、奇亚籽和姜黄素提取物制成的功能性食品对儿童肥胖大鼠模型的代谢和行为可能产生的有益影响。选用来自两窝不同大小的雄性Wistar幼鼠，一窝正常（NL）（10只幼鼠），一窝较小（SL）（4只幼鼠）。断奶后，给大鼠喂食高热量饮食（HD）或补充功能性食品混合物的HD。测量七周内的体重和能量摄入量，并进行运动活动、学习和记忆测试。实验结束时，测定葡萄糖和脂质代谢参数。结果表明，在这种由早期过度喂养和食用高热量饮食导致的肥胖模型中，大鼠后代出现了焦虑样行为和代谢改变；然而，提供功能性食品未能减少或预防这些改变，甚至在一些代谢指标中观察到恶化。有趣的是，在NL大鼠中，提供功能性食品产生了一些预期的健康改善，如体重增加和肝脏胆固醇显著降低，脂肪组织以及瘦素和胰岛素血清水平无显著降低。
