Department of Inorganic Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
Department of Thermal Technology and Food Process Engineering, University of Life Sciences in Lublin, Głęboka 31, 20-612 Lublin, Poland.
Int J Mol Sci. 2022 Jan 7;23(2):639. doi: 10.3390/ijms23020639.
Obesity is a global health problem needing urgent research. Synthetic anti-obesity drugs show side effects and variable effectiveness. Thus, there is a tendency to use natural compounds for the management of obesity. There is a considerable body of knowledge, supported by rigorous experimental data, that natural polyphenols, including curcumin, can be an effective and safer alternative for managing obesity. Curcumin is a is an important compound present in L. rhizome. It is a lipophilic molecule that rapidly permeates cell membrane. Curcumin has been used as a pharmacological traditional medicinal agent in Ayurvedic medicine for ∼6000 years. This plant metabolite doubtless effectiveness has been reported through increasingly detailed in vitro, in vivo and clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes have been remarkably highlighted. This review documents the status of research on anti-obesity mechanisms and evaluates the effectiveness of curcumin for management of obesity. It summarizes different mechanisms of anti-obesity action, associated with the enzymes, energy expenditure, adipocyte differentiation, lipid metabolism, gut microbiota and anti-inflammatory potential of curcumin. However, there is still a need for systematic and targeted clinical studies before curcumin can be used as the mainstream therapy for managing obesity.
肥胖是一个全球性的健康问题，需要紧急研究。合成抗肥胖药物有副作用且效果不一。因此，人们倾向于使用天然化合物来治疗肥胖症。有大量的知识，支持严格的实验数据，表明天然多酚，包括姜黄素，可以作为管理肥胖的有效和更安全的替代方法。姜黄素是 L. 根茎中一种重要的化合物。它是一种亲脂性分子，能迅速穿透细胞膜。姜黄素已被用作阿育吠陀医学中一种药理学传统药物，约 6000 年。通过越来越详细的体外、体内和临床试验，这种植物代谢物无疑具有有效性。关于其生物学作用，多种促进健康、预防疾病甚至治疗的特性已经得到了显著的强调。本综述记录了抗肥胖机制的研究现状，并评估了姜黄素在肥胖症管理中的有效性。它总结了姜黄素的不同抗肥胖作用机制，与酶、能量消耗、脂肪细胞分化、脂质代谢、肠道微生物群和抗炎潜力有关。然而，在姜黄素可以作为管理肥胖的主流治疗方法之前，仍然需要进行系统和有针对性的临床研究。
