Eliot R S, Buell J C
J Am Coll Cardiol. 1985 Jun;5(6 Suppl):95B-98B. doi: 10.1016/s0735-1097(85)80535-0.
Emotional arousal induces dramatic endocrine responses through either the sympathetic-adrenal medullary system or pituitary-adrenal cortical system. Many of the known actions of cortisol and catecholamines are atherogenic, cardiotoxic and arrhythmogenic. Emotional stress can produce sudden cardiac death in experimental animals, as can the administration of exogenous catecholamines. Previous studies have found that emotional stress is a common precursor to sudden cardiac death. Thus, acute neuroendocrine arousal, superimposed on a substrate of compromised myocardium and electrical instability, may constitute an important, final inciting event in sudden cardiac death.
情绪激动通过交感 - 肾上腺髓质系统或垂体 - 肾上腺皮质系统引发显著的内分泌反应。皮质醇和儿茶酚胺的许多已知作用具有致动脉粥样硬化、心脏毒性和致心律失常性。情绪应激可在实验动物中导致心源性猝死，外源性儿茶酚胺的给药也可导致同样结果。先前的研究发现，情绪应激是心源性猝死的常见先兆。因此，叠加在心肌受损和电不稳定基础上的急性神经内分泌激动，可能是心源性猝死中一个重要的、最终的诱发事件。
