Lane R D, Schwartz G E
Psychosom Med. 1987 May-Jun;49(3):274-84. doi: 10.1097/00006842-198705000-00006.
A neurophysiologic mechanism for stress-induced cardiac arrhythmias is proposed based on the integration of two bodies of research that have until now developed independently: the role of hemispheric specialization in the mediation of emotional arousal and the role of a lateralized imbalance in sympathetic input to the heart in cardiac arrhythmogenesis. The specific hypothesis is that individuals who manifest more lateralized frontal lobe activity during emotional arousal may concomitantly generate more lateralized sympathetic input to the heart and be at increased risk for fatal cardiac arrhythmias. The theoretical background for the hypothesis is presented, empirical support for the hypothesis is reviewed, and implications for empirical research are discussed.
基于此前一直独立开展的两项研究成果的整合，提出了一种应激诱发心律失常的神经生理机制：半球特化在情绪唤醒调节中的作用，以及心脏交感神经输入的侧化失衡在心律失常发生中的作用。具体假设是，在情绪唤醒期间额叶活动表现出更多侧化的个体，可能同时会产生更多心脏侧化的交感神经输入，从而有更高的致命性心律失常风险。本文介绍了该假设的理论背景，回顾了对该假设的实证支持，并讨论了对实证研究的启示。
