Bumbie Gifty Ziema, Abormegah Leonardo, Asiedu Peter, Oduro-Owusu Akua Durowaa, Koranteng Achiamaa Asafu-Adjaye, Ansah Kwabena Owusu, Lamptey Vida Korkor, Chen Chen, Mohamed Taha Mohamed, Tang Zhiru
Laboratory for Bio-Feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Council for Scientific and Industrial Research, Animal Research Institute, Accra 20, Ghana.
Animals (Basel). 2024 Jun 4;14(11):1676. doi: 10.3390/ani14111676.
This study evaluated the effects of GT001 on ()-challenged broiler chickens. Two hundred Ross 708 broiler day-old chicks with comparable weight were distributed at random into four treatments with five replicates and ten chicks per replicate. The following were the treatment groups: (B) basal diet (control); (B + S) basal diet and birds were challenged with at 1.0 × 10 cfu/g; (B + P) basal diet + GT001 at 4.0 × 10 cfu/g; (B + P + S) basal diet + GT001 at 4.0 × 10 cfu/g and birds were challenged with at 1.0 × 10 cfu/g. There was a significant reduction ( < 0.05) in the body weight of the -infected birds compared to the other treatment groups. However, the FCRs of the broilers were comparable among the different treatment groups ( > 0.05). The lipid profile and liver function indices measured were significantly enhanced in the GT001-supplemented groups (B + P and B + P + S) compared to the group that was -challenged ( < 0.05) but were similar to those in the control group. The serum antioxidant activities, such as the T-AOC, SOD, CAT, GHS-Px and MDA, were significantly improved in the GT001-supplemented groups (B + P and B + P + S) ( < 0.05). The MDA was similar in the B + P and B + P + S groups, but both were significantly lower than the control and the groups. The administration of GT001 enhanced the lipase and amylase levels in both the serum and intestine of the broilers ( < 0.05). The immunoglobin (IgA, IgG, IgM) and cytokine (IL-10 and IL-6) levels in the serum were significantly higher in the B, B + P and B + P + S treatment groups ( < 0.05). The immune-related organs (bursa and spleen) were significantly influenced in the birds fed with GT001. No significant variation was noted among all the dietary treatments in terms of the measured meat quality indices. The small intestinal digesta content of the load was below a detectable range after 14 days of infection ( < 0.05). No significant differences were observed among the different treatment groups in terms of the breast pH, drip loss and meat color ( > 0.05). The inclusion of GT001 also modified the community structure in the cecum. This indicates that it has health benefits and could be incorporated in the broiler diet.
本研究评估了GT001对受（）挑战的肉鸡的影响。200只体重相当的罗斯708一日龄肉鸡随机分为四个处理组，每组五个重复，每个重复十只鸡。处理组如下：（B）基础日粮（对照组）；（B + S）基础日粮，鸡只以1.0×10 cfu/g的（）进行攻毒；（B + P）基础日粮 + 4.0×10 cfu/g的GT001；（B + P + S）基础日粮 + 4.0×10 cfu/g的GT001，鸡只以1.0×10 cfu/g的（）进行攻毒。与其他处理组相比，受（）感染鸡只的体重显著降低（P < 0.05）。然而，不同处理组肉鸡的料重比相当（P > 0.05）。与受（）攻毒组相比，补充GT001的组（B + P和B + P + S）所测血脂谱和肝功能指标显著提高（P < 0.05），但与对照组相似。补充GT001的组（B + P和B + P + S）血清抗氧化活性，如总抗氧化能力（T-AOC）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GHS-Px）和丙二醛（MDA）显著改善（P < 0.05）。B + P组和B + P + S组的MDA相似，但均显著低于对照组和（）组。GT001的添加提高了肉鸡血清和肠道中的脂肪酶和淀粉酶水平（P < 0.05）。B、B + P和B + P + S处理组血清中的免疫球蛋白（IgA、IgG、IgM）和细胞因子（IL-10和IL-6）水平显著更高（P < 0.05）。饲喂GT001的鸡只免疫相关器官（法氏囊和脾脏）受到显著影响。在所测肉质指标方面，所有日粮处理之间未观察到显著差异。感染14天后，（）负荷的小肠消化物含量低于可检测范围（P < 0.05）。不同处理组在胸肉pH值、滴水损失和肉色方面未观察到显著差异（P > 0.05）。GT001的添加还改变了盲肠中的群落结构。这表明它具有健康益处，可纳入肉鸡日粮中。
