Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Int J Mol Sci. 2024 May 21;25(11):5584. doi: 10.3390/ijms25115584.
As one of the emerging hallmarks of tumorigenesis and tumor progression, metabolic remodeling is common in the tumor microenvironment. Hepatocellular carcinoma (HCC) is the third leading cause of global tumor-related mortality, causing a series of metabolic alterations in response to nutrient availability and consumption to fulfill the demands of biosynthesis and carcinogenesis. Despite the efficacy of immunotherapy in treating HCC, the response rate remains unsatisfactory. Recently, research has focused on metabolic reprogramming and its effects on the immune state of the tumor microenvironment, and immune response rate. In this review, we delineate the metabolic reprogramming observed in HCC and its influence on the tumor immune microenvironment. We discuss strategies aimed at enhancing response rates and overcoming immune resistance through metabolic interventions, focusing on targeting glucose, lipid, or amino acid metabolism, as well as systemic regulation.
作为肿瘤发生和肿瘤进展的新兴标志之一，代谢重编程在肿瘤微环境中很常见。肝细胞癌（HCC）是全球肿瘤相关死亡的第三大致病原因，为了满足生物合成和致癌作用的需求，它会对营养物质的可利用性和消耗做出一系列代谢改变。尽管免疫疗法在治疗 HCC 方面具有疗效，但响应率仍不尽如人意。最近，研究的重点集中在代谢重编程及其对肿瘤免疫微环境和免疫反应率的影响上。在这篇综述中，我们描述了 HCC 中观察到的代谢重编程及其对肿瘤免疫微环境的影响。我们讨论了通过代谢干预来提高响应率和克服免疫抵抗的策略，重点是针对葡萄糖、脂质或氨基酸代谢以及系统调节。
