Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, China.
Front Immunol. 2024 Aug 7;15:1429812. doi: 10.3389/fimmu.2024.1429812. eCollection 2024.
Hepatocellular carcinoma (HCC) is a highly frequent malignancy worldwide. The occurrence and progression of HCC is a complex process closely related to the polarization of tumor-associated macrophages (TAMs) in the tumor microenvironment (TME). The polarization of TAMs is affected by a variety of signaling pathways and surrounding cells. Evidence has shown that TAMs play a crucial role in HCC, through its interaction with other immune cells in the TME. This review summarizes the origin and phenotypic polarization of TAMs, their potential impacts on HCC, and their mechanisms and potential targets for HCC immunotherapy.
肝细胞癌（HCC）是一种在全球范围内高发的恶性肿瘤。HCC 的发生和发展是一个复杂的过程，与肿瘤微环境（TME）中肿瘤相关巨噬细胞（TAMs）的极化密切相关。TAMs 的极化受多种信号通路和周围细胞的影响。有证据表明，TAMs 通过与 TME 中的其他免疫细胞相互作用，在 HCC 中发挥关键作用。本综述总结了 TAMs 的起源和表型极化、它们对 HCC 的潜在影响，以及它们在 HCC 免疫治疗中的机制和潜在靶点。
