Department of Nephrology, University of Medicine and Pharmacy "Iuliu Hatieganu", 400012 Cluj-Napoca, Romania.
"Mihai Manasia" Nephrology and Dialysis Clinic, County Emergency Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania.
Int J Mol Sci. 2024 May 23;25(11):5696. doi: 10.3390/ijms25115696.
Pro-B amino-terminal natriuretic peptide (NT-proBNP) is a diagnostic marker for heart failure (HF), a severe complication of chronic kidney disease (CKD). However, its significance in CKD is not clear, as other factors, such as renal function, may also have an impact. Recent studies have shown that ghrelin treatment is effective in HF in the general population, but the impact of ghrelin on cardiac function in CKD patients is still unknown. Our study aimed to investigate the factors associated with NT-proBNP in pre-dialysis CKD patients and to evaluate the correlation between NT-proBNP and ghrelin and acyl-ghrelin, molecules determined using ELISA methods. In a cross-sectional observational study, we included 80 patients with pre-dialysis CKD, with a mean age of 68 years and 50% men. The median values for NT-proBNP were 351.8 pg/mL, for acyl ghrelin 16.39 pg/mL, and for ghrelin 543.32 pg/mL. NT-proBNP was correlated with ghrelin ( = 0.034, r = 0.24), acyl-ghrelin ( = 0.033, r = -0.24), estimated glomerular filtration rate ( = 0.027, r = -0.25), serum urea ( = 0.006, r = 0.31), and ferritin ( = 0.041, r = 0.28). In multivariate analysis, ghrelin ( = 0.040) and blood urea ( = 0.040) remained significant predictors for NT-proBNP levels. NT-proBNP was a significant predictor for acyl-ghrelin ( = 0.036). In conclusion, in pre-dialysis CKD patients, a high value of NT-proBNP was associated with a high value of total ghrelin and a low value of acyl-ghrelin.
脑钠肽前体（NT-proBNP）是心力衰竭（HF）的诊断标志物，HF 是慢性肾脏病（CKD）的严重并发症。然而，其在 CKD 中的意义尚不清楚，因为其他因素，如肾功能，也可能有影响。最近的研究表明，ghrelin 治疗对一般人群的 HF 有效，但 ghrelin 对 CKD 患者心脏功能的影响尚不清楚。我们的研究旨在探讨透析前 CKD 患者中与 NT-proBNP 相关的因素，并评估 NT-proBNP 与 ghrelin 和酰基-ghrelin 之间的相关性，这些分子是使用 ELISA 方法确定的。在一项横断面观察性研究中，我们纳入了 80 例透析前 CKD 患者，平均年龄 68 岁，50%为男性。NT-proBNP 的中位数为 351.8pg/ml，酰基-ghrelin 为 16.39pg/ml，ghrelin 为 543.32pg/ml。NT-proBNP 与 ghrelin（ = 0.034，r = 0.24）、酰基-ghrelin（ = 0.033，r = -0.24）、估算肾小球滤过率（ = 0.027，r = -0.25）、血清尿素（ = 0.006，r = 0.31）和铁蛋白（ = 0.041，r = 0.28）呈正相关。多元分析显示，ghrelin（ = 0.040）和血尿素（ = 0.040）仍是 NT-proBNP 水平的显著预测因子。NT-proBNP 是酰基-ghrelin（ = 0.036）的显著预测因子。结论：在透析前 CKD 患者中，NT-proBNP 水平升高与总 ghrelin 水平升高和酰基-ghrelin 水平降低有关。
