通过控制血糖保护脑缺血中粗制线粒体制剂的呼吸作用
Protection of respiration of a crude mitochondrial preparation in cerebral ischaemia by control of blood glucose.
作者信息
Strong A J, Miller S A, West I C
出版信息
J Neurol Neurosurg Psychiatry. 1985 May;48(5):450-4. doi: 10.1136/jnnp.48.5.450.
Abstract
There is evidence that systemic hyperglycaemia influences the evolution of cerebral ischaemia adversely, through enhancement of brain lactic acidosis. A potential protective regimen based on induction of mild hypoglycaemia with insulin was therefore studied. Respiratory control in brain mitochondria prepared from the ischaemic hemisphere of rats subjected to unilateral common carotid artery occlusion for one hour was abolished, but was partially preserved in insulin-treated rats (p = 0.01).
摘要
有证据表明，全身性高血糖通过增强脑乳酸酸中毒对脑缺血的发展产生不利影响。因此，研究了一种基于胰岛素诱导轻度低血糖的潜在保护方案。在接受单侧颈总动脉闭塞一小时的大鼠缺血半球制备的脑线粒体中，呼吸控制被消除，但在胰岛素治疗的大鼠中部分得以保留（p = 0.01）。
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