Department of Forest Biomaterials Engineering, Kangwon National University, Chuncheon 24341, Republic of Korea.
Dr.Oregonin Inc., #802 Bodeum Hall, Kangwondaehakgil 1, Chuncheon 24341, Republic of Korea.
Int J Mol Sci. 2024 Jun 4;25(11):6197. doi: 10.3390/ijms25116197.
Aging leads to tissue and cellular changes, often driven by oxidative stress and inflammation, which contribute to age-related diseases. Our research focuses on harnessing the potent anti-inflammatory and antioxidant properties of Korean Hance, a traditional herbal remedy, to address muscle loss and atrophy. We evaluated the effects of extract on various parameters in a muscle atrophy model, including weight, exercise performance, grip strength, body composition, muscle mass, and fiber characteristics. Additionally, we conducted Western blot and RT-PCR analyses to examine muscle protein regulation, apoptosis factors, inflammation, and antioxidants. In a dexamethasone-induced muscle atrophy model, extract administration promoted genes related to muscle formation while reducing those associated with muscle atrophy. It also mitigated inflammation and boosted muscle antioxidants, indicating a potential improvement in muscle atrophy. These findings highlight the promise of extract for developing pharmaceuticals and supplements to combat muscle loss and atrophy, paving the way for clinical applications.
衰老是导致组织和细胞变化的原因，通常是由氧化应激和炎症引起的，这些变化导致了与年龄相关的疾病。我们的研究重点是利用韩国传统草药红参的强大抗炎和抗氧化特性，来解决肌肉减少和萎缩的问题。我们评估了 提取物对肌肉萎缩模型中各种参数的影响，包括体重、运动性能、握力、身体成分、肌肉质量和纤维特征。此外，我们还进行了 Western blot 和 RT-PCR 分析，以研究肌肉蛋白调节、细胞凋亡因子、炎症和抗氧化剂。在 dexamethasone 诱导的肌肉萎缩模型中， 提取物的给药促进了与肌肉形成相关的基因，同时减少了与肌肉萎缩相关的基因。它还减轻了炎症并增强了肌肉抗氧化剂，表明 提取物有可能改善肌肉萎缩。这些发现突显了 提取物在开发用于对抗肌肉减少和萎缩的药物和补充剂方面的潜力，为临床应用铺平了道路。
