Endocrinology and Nutrition Unit, University Hospital Clínico San Cecilio, 18016 Granada, Spain.
Instituto de Investigación Biosanitaria de Granada (Ibs. Granada), 18014 Granada, Spain.
Int J Mol Sci. 2023 Feb 24;24(5):4491. doi: 10.3390/ijms24054491.
The life expectancy of the global population has increased. Aging is a natural physiological process that poses major challenges in an increasingly long-lived and frail population. Several molecular mechanisms are involved in aging. Likewise, the gut microbiota, which is influenced by environmental factors such as diet, plays a crucial role in the modulation of these mechanisms. The Mediterranean diet, as well as the components present in it, offer some proof of this. Achieving healthy aging should be focused on the promotion of healthy lifestyle habits that reduce the development of pathologies that are associated with aging, in order to increase the quality of life of the aging population. In this review we analyze the influence of the Mediterranean diet on the molecular pathways and the microbiota associated with more favorable aging patterns, as well as its possible role as an anti-aging treatment.
全球人口的预期寿命有所增加。衰老是一个自然的生理过程,在一个寿命越来越长且身体虚弱的人群中带来了重大挑战。几种分子机制与衰老有关。同样,受饮食等环境因素影响的肠道微生物群在调节这些机制方面起着至关重要的作用。地中海饮食以及其中存在的成分为此提供了一些证据。实现健康老龄化应该侧重于促进健康的生活方式习惯,以减少与衰老相关的疾病的发展,从而提高老龄化人口的生活质量。在这篇综述中,我们分析了地中海饮食对与更有利的衰老模式相关的分子途径和微生物群的影响,以及它作为抗衰老治疗的可能作用。