Chodick Gabriel, Barer Yael, Blay Hagai Tal, Keidar Ido, Rosenfeld Teper Gally, Kopel Hagit, Berkman Neville
Maccabitech, Maccabi Institute for Research and Innovation, Maccabi Healthcare Services, Ha'Mered St. 27, Tel Aviv 6812509, Israel.
Sackler School of Medicine, Tel Aviv University, P.O. Box 39040, Ramat Aviv, Tel Aviv 6997801, Israel.
J Clin Med. 2024 May 30;13(11):3230. doi: 10.3390/jcm13113230.
Chronic cough (CC) is a prevalent yet underexplored medical condition, with limited real-world data regarding its healthcare burden. This study investigates the epidemiology, associated comorbidities, and healthcare service utilization among patients with CC. In this retrospective cohort study, adult patients with at least 3 physician diagnoses of cough over a period spanning a minimum of 8 weeks and a maximum of 12 months anytime between 2009 and 2018, were defined as patients with CC (PwCC). The reference group were adults without cough matched in a 1:1 ratio for age, sex, and place of residence. The study included 91,757 PwCC, reflecting a prevalence of 5.5%. Of those, 59,296 patients (mean [SD] age, 53.9 [16.8] years; 59.6% females) were first diagnosed with CC during the study period, representing a 10-year incidence rate of 3.26% (95%CI: 3.24-3.29%). Diseases associated with the highest OR for CC included lung cancer (OR = 3.32; 95%CI: 2.90-4.25), whooping cough (OR = 3.04; 95%CI: 2.70-3.60), and respiratory infections (OR = 2.81; 95%CI: 2.74-2.88). Furthermore, PwCC demonstrated increased healthcare service utilization, leading to a higher adjusted annual estimated mean cost (USD 4038 vs. USD 1833, < 0.001). Chronic cough emerges as a relatively prevalent complaint within community care, exerting a considerable economic burden. This study underscores the need for heightened awareness, comprehensive management strategies, and resource allocation to address the multifaceted challenges associated with chronic cough.
慢性咳嗽（CC）是一种普遍存在但尚未得到充分研究的病症，关于其医疗负担的真实世界数据有限。本研究调查了慢性咳嗽患者的流行病学、相关合并症以及医疗服务利用情况。在这项回顾性队列研究中，2009年至2018年期间，至少有3次医生诊断为咳嗽，且咳嗽持续时间最短8周、最长12个月的成年患者被定义为慢性咳嗽患者（PwCC）。对照组为年龄、性别和居住地点按1:1比例匹配的无咳嗽成年人。该研究纳入了91,757例慢性咳嗽患者，患病率为5.5%。其中，59,296例患者（平均[标准差]年龄为53.9[16.8]岁；59.6%为女性）在研究期间首次被诊断为慢性咳嗽，10年发病率为3.26%（95%置信区间：3.24 - 3.29%）。与慢性咳嗽关联度最高的疾病包括肺癌（比值比 = 3.32；95%置信区间：2.90 - 4.25）、百日咳（比值比 = 3.04；95%置信区间：2.70 - 3.60）和呼吸道感染（比值比 = 2.81；95%置信区间：2.74 - 2.88）。此外，慢性咳嗽患者的医疗服务利用率增加，导致调整后的年度估计平均成本更高（4038美元对1833美元，< 0.001）。慢性咳嗽在社区护理中是一种相对常见的病症，会带来相当大的经济负担。本研究强调需要提高认识、制定全面的管理策略并进行资源分配，以应对与慢性咳嗽相关的多方面挑战。
