Pala Barbara, Pennazzi Laura, Nardoianni Giulia, Fogacci Federica, Cicero Arrigo F G, Di Renzo Laura, Barbato Emanuele, Tocci Giuliano
Division of Cardiology, Department of Clinical and Molecular Medicine, University of Rome Sapienza, Sant'Andrea Hospital, 00189 Rome, Italy.
Department of Obstetric Sciences, Faculty of Medicine and Surgery, Catholic University Sacro Cuore, 00168 Rome, Italy.
J Clin Med. 2024 May 31;13(11):3254. doi: 10.3390/jcm13113254.
Over the past decade, the gut microbiome (GM) has progressively demonstrated to have a central role in human metabolism, immunity, and cardiometabolic risk. Likewise, sleep disorders showed an impact on individual health and cardiometabolic risk. Recent studies seem to suggest multi-directional relations among GM, diet, sleep, and cardiometabolic risk, though specific interactions are not fully elucidated. We conducted a systematic review to synthesize the currently available evidence on the potential interactions between sleep and GM and their possible implications on cardiometabolic risk. A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews and meta-analyses, including articles from January 2016 until November 2022. Narrative syntheses were employed to describe the results. A total of 8 studies were selected according to these criteria. Our findings indicated that the sleep disorder and/or the acute circadian rhythm disturbance caused by sleep-wake shifts affected the human GM, mainly throughout microbial functionality. Sleep disorders should be viewed as cardiovascular risk factors and targeted for preventive intervention. More research and well-designed studies are needed to completely assess the role of sleep deprivation in the multi-directional relationship between GM and cardiometabolic risk.
在过去十年中，肠道微生物群（GM）已逐渐证明在人类新陈代谢、免疫和心血管代谢风险中起着核心作用。同样，睡眠障碍也对个体健康和心血管代谢风险产生影响。最近的研究似乎表明GM、饮食、睡眠和心血管代谢风险之间存在多向关系，尽管具体的相互作用尚未完全阐明。我们进行了一项系统综述，以综合目前关于睡眠与GM之间潜在相互作用及其对心血管代谢风险可能影响的现有证据。根据系统评价和Meta分析的首选报告项目（PRISMA）声明进行系统综述，以报告系统评价和Meta分析，包括2016年1月至2022年11月的文章。采用叙述性综合方法描述结果。根据这些标准共筛选出8项研究。我们的研究结果表明，睡眠障碍和/或由睡眠-觉醒转换引起的急性昼夜节律紊乱会影响人类GM，主要是通过微生物功能。睡眠障碍应被视为心血管危险因素，并应进行预防性干预。需要更多的研究和精心设计的研究来全面评估睡眠剥夺在GM与心血管代谢风险多向关系中的作用。
