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用于基底细胞癌治疗的局部和瘤内免疫疗法

Topical and Intralesional Immunotherapy for the Management of Basal Cell Carcinoma.

作者信息

Fernández-Galván Aurora, Rodríguez-Jiménez Pedro, González-Sixto Beatriz, Abalde-Pintos María Teresa, Butrón-Bris Beatriz

机构信息

Dermatology Department, Hospital Universitario La Princesa, Diego de León St. 62, 28006 Madrid, Spain.

Dermatology Department, Hospital Ruber Internacional, 28034 Madrid, Spain.

出版信息

Cancers (Basel). 2024 Jun 4;16(11):2135. doi: 10.3390/cancers16112135.

DOI:10.3390/cancers16112135
PMID:38893254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11172323/
Abstract

Basal Cell Carcinoma (BCC) is the most common type of cancer among the white population. Individuals with fair skin have an average lifetime risk of around 30% for developing BCC, and there is a noticeable upward trend in its incidence rate. The principal treatment objectives for BCC involve achieving the total excision of the tumor while maximizing the preservation of function and cosmesis. Surgery is considered the treatment of choice for BCC for two main reasons: it allows for the highest cure rates and facilitates histological control of resection margins. However, in the subgroup of patients with low-risk recurrence or medical contraindications for surgery, new non-surgical treatment alternatives can provide an excellent oncological and cosmetic outcome. An evident and justified instance of these local therapies occurred during the COVID-19 pandemic, a period when surgical interventions carried out in hospital settings were not a viable option.

摘要

基底细胞癌(BCC)是白种人群中最常见的癌症类型。皮肤白皙的个体患基底细胞癌的终生平均风险约为30%,且其发病率呈明显上升趋势。基底细胞癌的主要治疗目标是在最大程度保留功能和美观的同时实现肿瘤的完全切除。手术被认为是基底细胞癌的首选治疗方法,主要有两个原因:它能实现最高的治愈率,并有助于对切除边缘进行组织学控制。然而,在复发风险低或有手术医学禁忌证的患者亚组中,新的非手术治疗选择可以提供出色的肿瘤学和美容效果。在2019年冠状病毒病(COVID-19)大流行期间,这些局部治疗方法有一个明显且合理的应用实例,在那段时间里,在医院环境中进行手术干预并非可行选择。

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J Clin Med. 2024 Sep 26;13(19):5730. doi: 10.3390/jcm13195730.
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Retrospective Analysis of Clinicopathological Characteristics of Surgically Treated Basal Cell Carcinomas of the Face: A Single-Centre Maxillofacial Surgery Experience.面部基底细胞癌手术治疗的临床病理特征回顾性分析:单中心颌面外科经验
J Clin Med. 2024 Sep 14;13(18):5470. doi: 10.3390/jcm13185470.

本文引用的文献

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An Bras Dermatol. 2024 May-Jun;99(3):391-397. doi: 10.1016/j.abd.2023.08.009. Epub 2024 Feb 20.
2
Comparative Analysis of US Guidelines for the Management of Cutaneous Squamous Cell and Basal Cell Carcinoma.美国皮肤鳞状细胞癌和基底细胞癌管理指南的比较分析
J Skin Cancer. 2024 Feb 9;2024:3859066. doi: 10.1155/2024/3859066. eCollection 2024.
3
Clinical Efficacy of 5-Fluorouracil and Bleomycin in Dermatology.5-氟尿嘧啶与博来霉素在皮肤科的临床疗效
J Clin Med. 2024 Jan 6;13(2):335. doi: 10.3390/jcm13020335.
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Basal Cell Skin Cancer, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology.基底细胞癌临床实践指南 2.2024 版,NCCN 肿瘤学临床实践指南。
J Natl Compr Canc Netw. 2023 Nov;21(11):1181-1203. doi: 10.6004/jnccn.2023.0056.
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Tirbanibulin ointment to manage recurrence of superficial basal cell carcinoma of the face: case report.替瑞布林软膏治疗面部浅表基底细胞癌复发:病例报告
Clin Exp Dermatol. 2024 Jan 25;49(2):183-185. doi: 10.1093/ced/llad334.
6
European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023.欧洲基于共识的多学科指南:基底细胞癌的诊断和治疗——2023 年更新版。
Eur J Cancer. 2023 Oct;192:113254. doi: 10.1016/j.ejca.2023.113254. Epub 2023 Jul 28.
7
Topical Treatments for Basal Cell Carcinoma and Actinic Keratosis in the United States.美国基底细胞癌和光化性角化病的局部治疗方法
Cancers (Basel). 2023 Aug 2;15(15):3927. doi: 10.3390/cancers15153927.
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Life (Basel). 2023 Jun 1;13(6):1310. doi: 10.3390/life13061310.
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Recurrent Deeply Invasive Basal Cell Carcinoma.复发性深部侵袭性基底细胞癌。
J Craniofac Surg. 2023;34(8):e731-e733. doi: 10.1097/SCS.0000000000009497. Epub 2023 Jun 16.
10
Treatment of basal cell carcinoma with intralesional interferon alfa-2b: an open-label clinical trial.局部注射干扰素 α-2b 治疗基底细胞癌:一项开放性临床试验。
Expert Rev Anticancer Ther. 2023 Jul;23(7):753-760. doi: 10.1080/14737140.2023.2219449. Epub 2023 Jun 5.