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[鼻基底细胞癌]

[Basal cell carcinoma of the nose].

作者信息

Bonvallot T, Raulo Y, Zeller J, Faivre J M, Horn G, Baruch J

机构信息

Service de Chirurgie Plastique et Esthétique, Hôpital Henri Mondor, Créteil.

出版信息

Ann Dermatol Venereol. 1993;120(3):209-14.

PMID:8239358
Abstract

UNLABELLED

The purpose of this study of 81 patients with basal cell carcinoma (BCC) of the nose was to present the oncological and cosmetic results of surgical treatment and compare these results with those of other possible treatments.

MATERIAL AND METHOD

We report a series of 81 cases of histologically proven BCC of the nose located chiefly on the alae nasi and on the lower end of this organ; 42 p. 100 of the tumors had previously been treated and had recurred. The patients' mean age was 63 years, and the shortest follow-up was 3 years. Excision of the tumor under simple or reinforced local anaesthesia was complete in 88 p. 100 of the cases, incomplete or borderline in 12 p. 100 and systematically repeated. Extemporaneous histological examination was performed in 18 p. 100 of the cases. The operative lesion was repaired with a graft or a flap. There was no postsurgical treatment.

RESULTS

The recurrence rate was 4 p. 100 with a minimum follow-up of 3 years. The cosmetic result was good in 78 p. 100 of the patients.

DISCUSSION

Numerous treatments have been used against BCC of the nose, the results, advantages and disadvantages of each of these treatments are given below: 1. Cryosurgery. The problem with this method is that it is relatively difficult to perform and requires reliable operators. The cure rate is similar to that of other treatments. 2. Chemotherapy is not frequently used. 3. Electrocoagulation. Contrary to the conventional excision, this method precludes all histological controls, and the common idea of good oncological results is now being revised. 4. Radiotherapy. The recurrence rate varies from 7 to 11.8 p. 100 with fair cosmetic results. It requires numerous sessions, cannot be repeated in case of recurrence and complicates the surgical treatment. In addition, there is a long-term risk of radiodystrophy. 5. Curietherapy by local implantation of 192Iridium has a recurrence rate of 2.5 to 7 p. 100. This treatment requires hospitalization and is costly. It is indicated in cases of complex surgery, difficult conventional radiotherapy and above all, sclerodermatous BCC. 6. Surgery has a recurrence rate which varies from 3.7 to 12.6 p. 100. Recurrences are due to insufficient excision, and this underlines the value of histological control which can be done only at surgery. It is a rapid and ambulatory treatment, usually performed under local anaesthesia. The cosmetic result is good (85 to 90 p. 100) and the patients must be made aware of this preoperatively with some degree of reliability, depending on age, location, size of BCC and on the surgical technique utilized.

CONCLUSION

Surgical treatment of nasal BCC is safe, effective and rapid, with good oncological and cosmetic results, and it has many advantages over the other treatments.

摘要

未标注

本研究针对81例鼻基底细胞癌(BCC)患者,旨在呈现手术治疗的肿瘤学及美容效果,并将这些结果与其他可能的治疗方法的结果进行比较。

材料与方法

我们报告了一系列81例经组织学证实的鼻BCC病例,主要位于鼻翼及鼻器官下端;100分之42的肿瘤此前曾接受治疗且复发。患者平均年龄为63岁,最短随访时间为3年。88%的病例在单纯或强化局部麻醉下肿瘤切除完整,12%不完整或接近边缘并进行了系统性重复切除。18%的病例进行了术中组织学检查。手术创口用移植物或皮瓣修复。术后未进行其他治疗。

结果

随访至少3年,复发率为4%。78%的患者美容效果良好。

讨论

针对鼻BCC已采用了多种治疗方法,以下是每种治疗方法的结果、优缺点:1. 冷冻手术。该方法的问题在于操作相对困难,需要可靠的操作人员。治愈率与其他治疗方法相似。2. 化疗使用不频繁。3. 电凝术。与传统切除术不同,该方法无法进行所有组织学检查,目前对良好肿瘤学结果的普遍看法正在被修正。4. 放射治疗。复发率在7%至11.8%之间,美容效果尚可。需要多次治疗,复发时无法重复,且会使手术治疗复杂化。此外,存在放射性营养障碍的长期风险。5. 通过局部植入192铱进行近距离治疗,复发率为2.5%至7%。这种治疗需要住院且费用高昂。适用于复杂手术、传统放疗困难的病例,尤其是硬皮病样BCC。6. 手术的复发率在3.7%至12.6%之间。复发是由于切除不充分,这凸显了仅在手术时才能进行的组织学检查的价值。这是一种快速的门诊治疗,通常在局部麻醉下进行。美容效果良好(85%至90%),术前必须根据患者年龄、肿瘤位置、大小及所采用的手术技术,在一定可靠性程度上让患者了解这一点。

结论

鼻BCC的手术治疗安全、有效且迅速,具有良好的肿瘤学及美容效果,与其他治疗方法相比有许多优势。

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