Gao Zhenzhen, Zhou Xiaoming, Liu Dandan, Nie Baoshen, Lu Hanchong, Chen Xiaotong, Wu Jiahui, Li Lei, Wang Xuekun
State Key Laboratory for Macromolecule Drugs and Large-Scale Manufacturing, School of Pharmaceutical Sciences, Liaocheng University, Liaocheng 252059, China.
Molecules. 2024 May 31;29(11):2593. doi: 10.3390/molecules29112593.
In this paper, an interesting γ'-carbon 1,6-conjugate addition for phosphine-catalyzed α-succinimide substituted allenoates has been disclosed. A wide array of substrates was found to participate in the reaction, resulting in the production of diverse 4-diarylmethylated 3,4-disubstituted maleimides with satisfactory to outstanding yields. Furthermore, a plausible mechanism for the reaction was proposed by the investigators.
本文报道了一种有趣的膦催化α-琥珀酰亚胺取代的联烯酸酯的γ'-碳1,6-共轭加成反应。发现多种底物可参与该反应，以令人满意至优异的产率生成各种4-二芳基甲基化的3,4-二取代马来酰亚胺。此外，研究人员还提出了该反应可能的机理。
