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具有促氧化剂活性和抗菌性能的二氧化硅-聚（乙烯基吡咯烷酮）杂化材料的溶胶-凝胶合成。

Sol-Gel Synthesis of Silica-Poly (Vinylpyrrolidone) Hybrids with Prooxidant Activity and Antibacterial Properties.

机构信息

Institute of General and Inorganic Chemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 11, 1113 Sofia, Bulgaria.

Institute of Metal Science, Equipment and Technologies with Hydro- and Aerodynamics Centre "Acad. A. Balevski", Bulgarian Academy of Sciences, Shipchenski Prohod Str., 67, 1574 Sofia, Bulgaria.

出版信息

Molecules. 2024 Jun 5;29(11):2675. doi: 10.3390/molecules29112675.

DOI:10.3390/molecules29112675
PMID:38893548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11173412/
Abstract

The present work deals with the sol-gel synthesis of silica-poly (vinylpyrrolidone) hybrid materials. The nanohybrids (Si-PVP) have been prepared using an acidic catalyst at ambient temperature. Tetramethyl ortosilane (TMOS) was used as a silica precursor. Poly (vinylpyrrolidone) (PVP) was introduced into the reaction mixture as a solution in ethanol with a concentration of 20%. The XRD established that the as-prepared material is amorphous. The IR and Si MAS NMR spectra proved the formation of a polymerized silica network as well as the hydrogen bonding interactions between the silica matrix and OH hydrogens of the silanol groups. The TEM showed spherical particle formation along with increased agglomeration tendency. The efficacy of SiO/PVP nanoparticles as a potential antimicrobial agent against a wide range of bacteria was evaluated as bacteriostatic, using agar diffusion and spot tests. Combined effects of hybrid nanomaterial and antibiotics could significantly reduce the bactericidal concentrations of both the antibiotic and the particles, and they could also eliminate the antibiotic resistance of the pathogen. The registered prooxidant activity of the newly synthesized material was confirmative and explicatory for the antibacterial properties of the tested substance and its synergetic combination with antibiotics. The effect of new hybrid material on Crustacea was also estimated as harmless under concentration of 0.1 mg/mL.

摘要

本工作涉及二氧化硅-聚（聚乙烯吡咯烷酮）杂化材料的溶胶-凝胶合成。纳米杂化物（Si-PVP）是在环境温度下使用酸性催化剂制备的。四甲基原硅酸酯（TMOS）用作二氧化硅前体。聚乙烯吡咯烷酮（PVP）作为乙醇溶液引入反应混合物中，浓度为 20%。XRD 确定所制备的材料是无定形的。IR 和 Si MAS NMR 光谱证明了聚合二氧化硅网络的形成以及二氧化硅基质与硅醇基团的 OH 氢键之间的相互作用。TEM 显示了球形颗粒的形成以及团聚倾向的增加。使用琼脂扩散和点测试评估了 SiO/PVP 纳米颗粒作为潜在的抗菌剂对广泛的细菌的抑菌效果。杂化纳米材料和抗生素的联合作用可以显著降低抗生素和颗粒的杀菌浓度，并且还可以消除病原体的抗生素耐药性。新合成材料的注册促氧化剂活性证实并解释了测试物质的抗菌特性及其与抗生素的协同组合。在 0.1mg/mL 浓度下，新的杂化材料对甲壳类动物的影响也被评估为无害。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/fecbba573077/molecules-29-02675-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/102f8ced2dc6/molecules-29-02675-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/950d4d033aab/molecules-29-02675-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/bf4ac4a9a26b/molecules-29-02675-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/03a9102d510a/molecules-29-02675-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/64f6d825c29b/molecules-29-02675-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/f419b36a0d51/molecules-29-02675-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/fecbba573077/molecules-29-02675-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/9b3afab10cf9/molecules-29-02675-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/c5db8f7bd9eb/molecules-29-02675-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/50a29ef64491/molecules-29-02675-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/85cbf673c183/molecules-29-02675-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/e8b261b32f67/molecules-29-02675-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/5d45f7da4acd/molecules-29-02675-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/102f8ced2dc6/molecules-29-02675-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/950d4d033aab/molecules-29-02675-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/bf4ac4a9a26b/molecules-29-02675-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/03a9102d510a/molecules-29-02675-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/64f6d825c29b/molecules-29-02675-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/f419b36a0d51/molecules-29-02675-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b95a/11173412/fecbba573077/molecules-29-02675-g013.jpg

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