Lachance S L, Barry J M
J Urol. 1985 Jun;133(6):950-1. doi: 10.1016/s0022-5347(17)49326-8.
High doses of furosemide have been reported to reduce the requirement for dialysis following cadaveric kidney transplantation. Depending on recipient age, alternate cadaver kidney transplant recipients received infusions of 200 to 400 mg. furosemide just before restoration of renal circulation. All recipients received infusions of mannitol during the hour before renal revascularization. All 50 kidneys were preserved with intracellular electrolyte solutions. Mean cold storage times (33.4 plus or minus 11.4 hours for recipients given furosemide versus 35.7 plus or minus 12.3 hours for controls) were not significantly different between the 2 groups. There were no significant differences in first week dialysis requirement between recipients given furosemide and controls (75 versus 73 per cent, respectively), first day urine output (2.2 plus or minus 4.2 versus 1.0 plus or minus 0.81., respectively), 1-month serum creatinine nadirs (2.1 plus or minus 1.1 versus 1.9 plus or minus 1.1 mg . per dl., respectively) and 1-month function rate (92 versus 92 per cent, respectively). High doses of furosemide did not prevent significant acute tubular necrosis following human cadaveric kidney transplantation when the recipients also received infusions of mannitol.
据报道，高剂量的呋塞米可减少尸体肾移植后透析的需求。根据受者年龄，交替的尸体肾移植受者在恢复肾循环前接受200至400毫克呋塞米的输注。所有受者在肾血管重建前一小时接受甘露醇输注。所有50个肾脏均用细胞内电解质溶液保存。两组之间的平均冷保存时间（接受呋塞米的受者为33.4±11.4小时，对照组为35.7±12.3小时）无显著差异。接受呋塞米的受者和对照组在第一周透析需求（分别为75%对73%）、第一天尿量（分别为2.2±4.2对1.0±0.81）、1个月血清肌酐最低点（分别为2.1±1.1对1.9±1.1毫克/分升）和1个月功能率（分别为92%对92%）方面均无显著差异。当受者也接受甘露醇输注时，高剂量的呋塞米并不能预防人类尸体肾移植后显著的急性肾小管坏死。
