Silicon Austria Labs GmbH: Sensor Systems, 9524 Villach, Austria.
Central Research Test and Analysis Laboratory Application and Research Center, Ege University, 35100 Izmir, Turkey.
Biosensors (Basel). 2022 Jul 29;12(8):583. doi: 10.3390/bios12080583.
Many emerging technologies have the potential to improve health care by providing more personalized approaches or early diagnostic methods. In this review, we cover smartphone-based multiplexed sensors as affordable and portable sensing platforms for point-of-care devices. Multiplexing has been gaining attention recently for clinical diagnosis considering certain diseases require analysis of complex biological networks instead of single-marker analysis. Smartphones offer tremendous possibilities for on-site detection analysis due to their portability, high accessibility, fast sample processing, and robust imaging capabilities. Straightforward digital analysis and convenient user interfaces support networked health care systems and individualized health monitoring. Detailed biomarker profiling provides fast and accurate analysis for disease diagnosis for limited sample volume collection. Here, multiplexed smartphone-based assays with optical and electrochemical components are covered. Possible wireless or wired communication actuators and portable and wearable sensing integration for various sensing applications are discussed. The crucial features and the weaknesses of these devices are critically evaluated.
许多新兴技术有潜力通过提供更个性化的方法或早期诊断方法来改善医疗保健。在这篇综述中，我们介绍了基于智能手机的多路复用传感器，它们是用于即时检测设备的经济实惠且便携的传感平台。考虑到某些疾病需要分析复杂的生物网络而不是单一标志物分析，多路复用技术最近在临床诊断中受到关注。由于其便携性、高可及性、快速样品处理和强大的成像功能，智能手机为现场检测分析提供了巨大的可能性。简单的数字分析和方便的用户界面支持联网医疗系统和个性化健康监测。详细的生物标志物分析为有限样本量采集的疾病诊断提供了快速准确的分析。在这里，我们介绍了基于智能手机的光学和电化学多路复用检测方法。讨论了用于各种传感应用的无线或有线通信致动器以及便携式和可穿戴式传感集成。对这些设备的关键特性和弱点进行了批判性评估。
