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INTRODUCTION

Persistent endodontic infections (PEIs) mediated by bacterial biofilm mainly cause persistent periapical inflammation, resulting in recurrent periapical abscesses and progressive bone destruction. However, conventional root canal disinfectants are highly damaging to the tooth and periodontal tissue and ineffective in treating persistent root canal infections. Antimicrobial materials that are biocompatible with apical tissues and can eliminate PEIs-associated bacteria are urgently needed.

METHODS

Here, ε-poly (L-lysine) derived carbon quantum dots (PL-CQDs) are fabricated using pyrolysis to remove PEIs-associated bacterial biofilms.

RESULTS

Due to their ultra-small size, high positive charge, and active reactive oxygen species (ROS) generation capacity, PL-CQDs exhibit highly effective antibacterial activity against (), which is greatly dependent on PL-CQDs concentrations. 100 µg/mL PL-CQDs could kill in 5 min. Importantly, PL-CQDs effectively achieved a reduction of biofilms in the isolated teeth model, disrupting the dense structure of biofilms. PL-CQDs have acceptable cytocompatibility and hemocompatibility in vitro and good biosafety in vivo.

DISCUSSION

Thus, PL-CQDs provide a new strategy for treating -associated PEIs.

INTRODUCTION

METHODS

Here, ε-poly (L-lysine) derived carbon quantum dots (PL-CQDs) are fabricated using pyrolysis to remove PEIs-associated bacterial biofilms.

RESULTS

DISCUSSION

Thus, PL-CQDs provide a new strategy for treating -associated PEIs.

简介

由细菌生物膜介导的持续性根尖周感染（PEI）主要导致持续性根尖周炎症，导致复发性根尖周脓肿和进行性骨破坏。然而，传统的根管消毒剂对牙齿和牙周组织具有高度破坏性，并且在治疗持续性根管感染方面无效。急需具有与根尖组织生物相容性且能消除与 PEI 相关的细菌的抗菌材料。

方法

本文采用热解方法制备 ε-聚（L-赖氨酸）衍生的碳量子点（PL-CQDs），以去除与 PEI 相关的细菌生物膜。

结果

由于其超小尺寸、高正电荷和活性活性氧（ROS）生成能力，PL-CQDs 对（）表现出高度有效的抗菌活性，这极大地依赖于 PL-CQDs 的浓度。100μg/mL PL-CQDs 可在 5 分钟内杀死。重要的是，PL-CQDs 有效地减少了离体牙齿模型中的生物膜，破坏了生物膜的致密结构。PL-CQDs 在体外具有可接受的细胞相容性和血液相容性，在体内具有良好的生物安全性。