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雌雄鼠脑肾连接的性别二态性图谱。

Sex-Dimorphic Kidney-Brain Connectivity Map of Mice.

机构信息

Shenzhen Key Laboratory of Neuropsychiatric Modulation, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.

出版信息

Neurosci Bull. 2024 Oct;40(10):1445-1457. doi: 10.1007/s12264-024-01240-z. Epub 2024 Jun 19.

DOI:10.1007/s12264-024-01240-z
PMID:38896358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11422536/
Abstract

The kidneys are essential organs that help maintain homeostasis, and their function is regulated by the neural system. Despite the anatomical multi-synaptic connection between the central autonomic nuclei and the kidneys, it remains unclear whether there are any variations in neural connections between the nervous systems and the renal cortex and medulla in male and female mice. Here, we used the pseudorabies virus to map the central innervation network of the renal cortex and medulla in both sexes. The data revealed that specific brain regions displayed either a contralateral-bias or ipsilateral-bias pattern while kidney-innervating neurons distributed symmetrically in the midbrain and hindbrain. Sex differences were observed in the distribution of neurons connected to the left kidney, as well as those connected to the renal cortex and medulla. Our findings provide a comprehensive understanding of the brain-kidney network in both males and females and may help shed light on gender differences in kidney function and disease susceptibility in humans.

摘要

肾脏是维持体内平衡的重要器官，其功能受神经系统调节。尽管中枢自主神经核与肾脏之间存在解剖学上的多突触连接，但神经系统与雄性和雌性小鼠肾皮质和髓质之间的神经连接是否存在差异仍不清楚。在这里，我们使用伪狂犬病毒来描绘两性肾脏皮质和髓质的中枢神经支配网络。数据显示，特定的脑区表现出对侧偏向或同侧偏向的模式，而支配肾脏的神经元在中脑和后脑中对称分布。与左肾相连的神经元以及与肾皮质和髓质相连的神经元的分布存在性别差异。我们的研究结果提供了对男性和女性大脑-肾脏网络的全面了解，可能有助于揭示人类肾脏功能和疾病易感性的性别差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/7fc026fde6b1/12264_2024_1240_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/36e01d244f5f/12264_2024_1240_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/19614460b5ae/12264_2024_1240_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/361b580bd2ed/12264_2024_1240_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/a318ef13664e/12264_2024_1240_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/f17bdfcba414/12264_2024_1240_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/0f9ac1d9bbb4/12264_2024_1240_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/1a827de8fde0/12264_2024_1240_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/7fc026fde6b1/12264_2024_1240_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/36e01d244f5f/12264_2024_1240_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/19614460b5ae/12264_2024_1240_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/361b580bd2ed/12264_2024_1240_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/a318ef13664e/12264_2024_1240_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/f17bdfcba414/12264_2024_1240_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/0f9ac1d9bbb4/12264_2024_1240_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/1a827de8fde0/12264_2024_1240_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/849f/11422536/7fc026fde6b1/12264_2024_1240_Fig8_HTML.jpg

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A kidney-brain neural circuit drives progressive kidney damage and heart failure.肾脏-大脑神经回路导致进行性肾脏损伤和心力衰竭。
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Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions (EAPCI).
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