Yu Enbo, Li Jun, Wang Yue, Chen Ya, Xiao Fuhong, Deng Guo-Jun
Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, Hunan Province Key Laboratory of Green Organic Synthesis and Application, College of Chemistry, Xiangtan University, Xiangtan 411105, China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
J Org Chem. 2024 Jul 5;89(13):9287-9297. doi: 10.1021/acs.joc.4c00276. Epub 2024 Jun 19.
A copper-catalyzed three-component coupling reaction of styrene oxide, aryl iodide, and carbon disulfide for the construction of β-hydroxysulfides has been developed. In this process, readily available CS was used as the sulfur source to construct C-S bonds for the synthesis of phenyl-β-hydroxysulfides and (benzo[]thiazol)-β-hydroxysulfides. This process features mild reaction conditions, simple operation, and wide substrate scope (>50 examples).
已开发出一种用于构建β-羟基硫醚的铜催化的氧化苯乙烯、芳基碘化物和二硫化碳的三组分偶联反应。在此过程中，使用易于获得的二硫化碳作为硫源来构建碳-硫键，用于合成苯基-β-羟基硫醚和（苯并噻唑）-β-羟基硫醚。该过程具有反应条件温和、操作简单和底物范围广（>50个实例）的特点。
