Liu Xian, Hao Liqiang, Wang Yangyang, Ji Yafei
Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Chem Asian J. 2024 Jan 2;19(1):e202300901. doi: 10.1002/asia.202300901. Epub 2023 Nov 27.
Transition-mental-free multi-component hydroxysulfenylation of styrenes with NH SCN and water to from β-hydroxysulfides is established. The reaction mechanism proceeded via a domino reaction after a radical addition to 2-phenylimidazo[1,2-a]pyridines. This approach features a wide substrate scope and functional group compatibility, providing 34 compounds in acceptable yields.
实现了苯乙烯与NH SCN和水进行过渡态无金属多组分羟基硫化反应以形成β-羟基硫醚。该反应机理是在向2-苯基咪唑并[1,2-a]吡啶进行自由基加成后通过多米诺反应进行的。这种方法具有广泛的底物范围和官能团兼容性，以可接受的产率提供了34种化合物。
