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强啡肽原免疫反应性位于大鼠大脑皮层中与脑啡肽原免疫反应性不同的神经元中。

Prodynorphin immunoreactivity is located in different neurons than proenkephalin immunoreactivity in the cerebral cortex of rats.

作者信息

McGinty J F

出版信息

Neuropeptides. 1985 Feb;5(4-6):465-8. doi: 10.1016/0143-4179(85)90055-1.

DOI:10.1016/0143-4179(85)90055-1
PMID:3889694
Abstract

Reported here is a description of the distribution and cellular morphology of neurons containing dynorphin B immunoreactivity (IR) and a comparison with cells containing bovine adrenal medullary peptide IR in the cerebral cortex of colchicine treated rats. Dynorphin B-IR was found in bipolar and multipolar cells in neocortical layers II-III and V-VI and in pyramidal and polymorph cells in olfactory cortical layers II and III. In the hippocampus, dynorphin B-IR was found in dentate granule cells and multipolar cells. In Fisher rats, dynorphin B was also found in cells in the subiculum and in CA1. The extensive regional overlap in the distribution of cortical neurons containing prodynorphin and proenkephalin in IR prompted a detailed comparison of their localization. In double immunostained tissue, dynorphin B-IR was demonstrated to occur in different neurons than those containing BAM22P-IR in the cerebral cortex and hippocampus of rats.

摘要

本文报道了秋水仙碱处理大鼠大脑皮层中含强啡肽B免疫反应性(IR)的神经元的分布和细胞形态,并与含牛肾上腺髓质肽IR的细胞进行了比较。在新皮层II - III层和V - VI层的双极和多极细胞以及嗅皮层II层和III层的锥体细胞和多形细胞中发现了强啡肽B - IR。在海马体中,在齿状颗粒细胞和多极细胞中发现了强啡肽B - IR。在费希尔大鼠中,在下托和CA1区的细胞中也发现了强啡肽B。含前强啡肽和前脑啡肽的免疫反应性皮层神经元分布广泛的区域重叠促使对它们的定位进行详细比较。在双重免疫染色组织中,在大鼠大脑皮层和海马体中,强啡肽B - IR被证明存在于与含BAM22P - IR的神经元不同的神经元中。

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Prodynorphin immunoreactivity is located in different neurons than proenkephalin immunoreactivity in the cerebral cortex of rats.强啡肽原免疫反应性位于大鼠大脑皮层中与脑啡肽原免疫反应性不同的神经元中。
Neuropeptides. 1985 Feb;5(4-6):465-8. doi: 10.1016/0143-4179(85)90055-1.
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J Comp Neurol. 1989 Oct 15;288(3):353-86. doi: 10.1002/cne.902880302.

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