International Graduate Program of Veterinary Science and Technology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Graduate Program in Veterinary Pathobiology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand; Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
Vet J. 2024 Aug;306:106182. doi: 10.1016/j.tvjl.2024.106182. Epub 2024 Jun 17.
Algae-derived β-glucan has been widely used as a feed additive in the swine industry. The supplementation of β-glucan aims to improve growth performance and modulate the immunity of pigs. However, the potential effects of supplementing β-glucan from algae on immune responses in pigs-specifically antigen-specific immunity-must be determined. In this study, the effects of algae-derived β-glucan supplementation on growth performance, virus neutralising antibody and virus-specific T lymphocytes responses were investigated in pigs. Piglets (n=112 per treatment) were assigned to three treatments including non-supplemented group (control), β-glucan 100 g/ton supplemented group (BG100), and β-glucan 200 g/ton supplemented group (BG200). In this study, production performance of pigs was not found to be different between the experimental groups. Pigs supplemented with β-glucan exhibited high levels of classical swine fever virus (CSFV)-specific producing T lymphocytes and neutralising antibody titer, compared to the control group. Interestingly, supplementation of β-glucan significantly enhanced porcine reproductive and respiratory syndrome virus (PRRSV)-specific interferon-gamma (IFN-γ) producing T lymphocytes, including CD4, CD8, and CD4CD8 T lymphocyte subpopulations. Moreover, PRRS modified live vaccine (MLV) viremia was reduced in earlier for β-glucan-supplemented pigs compared to the control group. The findings indicate that the algae-derived β-glucan possesses biological potential as an immunomodulatory substance to enhance antiviral immunity, which may contribute to disease resistance in pigs.
藻类来源的β-葡聚糖已被广泛用作猪养殖业的饲料添加剂。β-葡聚糖的添加旨在改善生长性能并调节猪的免疫力。然而，必须确定藻类来源的β-葡聚糖对猪的免疫反应（特别是抗原特异性免疫）的潜在影响。在这项研究中，研究了藻类来源的β-葡聚糖对猪的生长性能、病毒中和抗体和病毒特异性 T 淋巴细胞反应的影响。仔猪（每组 112 头）分为三组，包括未添加组（对照组）、100g/吨β-葡聚糖添加组（BG100）和 200g/吨β-葡聚糖添加组（BG200）。在本研究中，实验组的猪生产性能没有差异。与对照组相比，添加β-葡聚糖的猪表现出高水平的经典猪瘟病毒（CSFV）特异性产生 T 淋巴细胞和中和抗体滴度。有趣的是，与对照组相比，β-葡聚糖的添加显著增强了猪繁殖与呼吸综合征病毒（PRRSV）特异性干扰素-γ（IFN-γ）产生 T 淋巴细胞，包括 CD4、CD8 和 CD4CD8 T 淋巴细胞亚群。此外，与对照组相比，β-葡聚糖添加组的 PRRS 活疫苗（MLV）病毒血症更早降低。这些发现表明，藻类来源的β-葡聚糖具有作为免疫调节剂的生物学潜力，可增强抗病毒免疫力，从而有助于提高猪的抗病能力。
