Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, People's Republic of China.
Department of Orthopaedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai 200072, People's Republic of China.
Int J Biol Macromol. 2024 Aug;274(Pt 2):133153. doi: 10.1016/j.ijbiomac.2024.133153. Epub 2024 Jun 17.
Titanium and titanium alloys are widely favored materials for orthopedic implants due to their exceptional mechanical properties and biological inertness. The additional benefit of sustained local release of bioactive substances further promotes bone tissue formation, thereby augmenting the osseointegration capacity of titanium implants and attracting increasing attention in bone tissue engineering. Among these bioactive substances, growth factors have shown remarkable osteogenic and angiogenic induction capabilities. Consequently, researchers have developed various physical, chemical, and biological loading techniques to incorporate growth factors into titanium implants, ensuring controlled release kinetics. In contrast to conventional treatment modalities, the localized release of growth factors from functionalized titanium implants not only enhances osseointegration but also reduces the risk of complications. This review provides a comprehensive examination of the types and mechanisms of growth factors, along with a detailed exploration of the methodologies used to load growth factors onto the surface of titanium implants. Moreover, it highlights recent advancements in the application of growth factors to the surface of titanium implants (Scheme 1). Finally, the review discusses current limitations and future prospects for growth factor-functionalized titanium implants. In summary, this paper presents cutting-edge design strategies aimed at enhancing the bone regenerative capacity of growth factor-functionalized titanium implants-a significant advancement in the field of enhanced bone regeneration.
钛及钛合金因其优异的机械性能和生物惰性而被广泛用作骨科植入物的理想材料。生物活性物质的持续局部释放的额外益处进一步促进了骨组织的形成，从而增强了钛植入物的骨整合能力，并在骨组织工程中引起了越来越多的关注。在这些生物活性物质中，生长因子表现出显著的成骨和血管生成诱导能力。因此，研究人员已经开发了各种物理、化学和生物负载技术将生长因子掺入钛植入物中，以确保控制释放动力学。与传统的治疗方式相比，功能化钛植入物中生长因子的局部释放不仅增强了骨整合，还降低了并发症的风险。本综述全面考察了生长因子的类型和作用机制，并详细探讨了将生长因子加载到钛植入物表面的方法。此外，还重点介绍了生长因子在钛植入物表面应用的最新进展（方案 1）。最后，本文讨论了生长因子功能化钛植入物的当前局限性和未来前景。总之，本文提出了旨在增强生长因子功能化钛植入物骨再生能力的前沿设计策略，这是增强骨再生领域的一项重大进展。
