Shanxi Medical University School and Hospital of Stomatology, Taiyuan 030001, Shanxi, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, Shanxi, China.
ACS Biomater Sci Eng. 2024 Jul 8;10(7):4093-4113. doi: 10.1021/acsbiomaterials.3c01756. Epub 2024 Jun 3.
Titanium (Ti) and its alloys are widely used biomaterials in bone repair. Although these biomaterials possess stable properties and good biocompatibility, the high elastic modulus and low surface activity of Ti implants have often been associated with infection, inflammation, and poor osteogenesis. Therefore, there is an urgent need to modify the surface of Ti implants, where changes in surface morphology or coatings loading can confer specific functions to help them adapt to the osseointegration formation phase and resist bacterial infection. This can further ensure a healthy microenvironment for bone regeneration as well as the promotion of immunomodulation, angiogenesis, and osteogenesis. Therefore, in this review, we evaluated various functional Ti implants after surface modification, both in terms of static modifications and dynamic response strategies, mainly focusing on the synergistic effects of antimicrobial activities and functionalized osteogenic. Finally, the current challenges and future perspectives are summarized to provide innovative and effective solutions for osseointegration and bone defect repair.
钛（Ti）及其合金是骨修复中广泛应用的生物材料。尽管这些生物材料具有稳定的性能和良好的生物相容性，但钛植入物的高弹性模量和低表面活性常常与感染、炎症和骨生成不良有关。因此，迫切需要对钛植入物的表面进行改性，通过改变表面形貌或涂层负载，可以赋予其特定的功能，帮助其适应骨整合形成阶段并抵抗细菌感染。这进一步确保了骨骼再生的健康微环境，并促进了免疫调节、血管生成和骨生成。因此，在这篇综述中，我们评估了经过表面改性的各种功能化钛植入物，包括静态改性和动态响应策略，主要关注抗菌活性和功能化成骨的协同作用。最后，总结了当前的挑战和未来展望，为骨整合和骨缺损修复提供了创新和有效的解决方案。
