Jehn U, Löwenberg B
Onkologie. 1985 Apr;8(2):97-8. doi: 10.1159/000215628.
The intensity of modern protocols for remission induction of acute nonlymphocytic leukemia presents a major problem in elderly patients because of toxicity. Most studies concerning this question indicate that in higher age groups (greater than 60 yrs.) remission incidence worsens and the death rate increases. Therefore, the purpose of this multicenter study is to prospectively compare survival and quality of life of two different therapeutic strategies: immediate intensive remission induction using Daunomycin and Cytosine Arabinoside (branch I) versus supportive care, "wait and see" policy, and palliative cytoreduction (branch II) with Hydroxyurea and Ara C when necessary. During the first 8 months after activating this study, 27 patients entered, 13 were randomized to branch I and 14 to branch II. It is too early to report meaningful results.
由于毒性问题，现代急性非淋巴细胞白血病缓解诱导方案的强度在老年患者中构成了一个主要问题。关于这个问题的大多数研究表明，在较高年龄组（大于60岁）中，缓解发生率恶化，死亡率增加。因此，这项多中心研究的目的是前瞻性地比较两种不同治疗策略的生存率和生活质量：使用柔红霉素和阿糖胞苷立即进行强化缓解诱导（第一组）与支持性治疗、“观察等待”策略以及必要时使用羟基脲和阿糖胞苷进行姑息性细胞减灭术（第二组）。在启动这项研究后的前8个月，有27名患者入组，13名被随机分配到第一组，14名被随机分配到第二组。现在报告有意义的结果还为时过早。
