Departament d'Endocrinologia i Nutrició, Hospital Son Llàtzer, Institut d'Investigació Sanitària Illes Balears (IdISBa), Ctra Manacor km 4, 07198 Palma de Mallorca, Baleares, Spain.
Departament d'Endocrinologia i Nutrició, Hospital Son Llàtzer, Institut d'Investigació Sanitària Illes Balears (IdISBa), Ctra Manacor km 4, 07198 Palma de Mallorca, Baleares, Spain.
Endocrinol Diabetes Nutr (Engl Ed). 2024 May;71(5):202-207. doi: 10.1016/j.endien.2024.02.007.
The global increase in the prevalence rates of overweight or obesity has also affected patients with type 1 diabetes (T1D), where this disease had traditionally been associated with a lean phenotype. On the other hand, the effect of obesity on new glycemic control metrics obtained from continuous glucose monitoring (CGM) in T1D is poorly understood. We wanted to assess whether there is any relationship between BMI (body mass index) and the different CGM metrics or HbA1c.
Two hundred and twenty-five patients with T1D (47.1% ♀, mean age 42.9±14.7 years) with a CGM for a minimum of 6 months were analysed by downloading their CGM and collecting clinical and anthropometric variables.
35.1% (79/225) of the T1D patients had overweight and 17.3% (39/225) lived with obesity, while the remaining 47.6% had a normal weight. A negative correlation was found between GMI (glucose management indicator) and BMI (-0.2; p=0.008) and HbA1c (-0.2; p=0.01). In contrast, a positive correlation was observed between the total dose of insulin and the BMI (0.3; p<0.0001). No significant correlations were found between BMI and other CGM metrics.
Overweight or obesity do not imply worse glycemic control in patients with T1D or less use of CGM. Possibly, and in order to achieve a good glycemic control, more units of insulin are necessary in these patients which, in turn, makes weight control more difficult.
超重或肥胖患病率在全球范围内的上升也影响了 1 型糖尿病（T1D）患者，在过去，这种疾病与消瘦表型有关。另一方面，肥胖对 T1D 患者连续血糖监测（CGM）获得的新血糖控制指标的影响知之甚少。我们想评估 BMI（体重指数）与不同 CGM 指标或 HbA1c 是否存在任何关系。
我们分析了 225 名至少使用 CGM 6 个月的 T1D 患者（47.1%♀，平均年龄 42.9±14.7 岁），通过下载他们的 CGM 并收集临床和人体测量学变量。
35.1%（79/225）的 T1D 患者超重，17.3%（39/225）患有肥胖症，而其余 47.6%的患者体重正常。GMI（血糖管理指标）与 BMI 呈负相关（-0.2；p=0.008）和 HbA1c（-0.2；p=0.01）。相比之下，胰岛素总剂量与 BMI 呈正相关（0.3；p<0.0001）。BMI 与其他 CGM 指标之间未发现显著相关性。
超重或肥胖并不意味着 T1D 患者的血糖控制更差或更少使用 CGM。可能为了达到良好的血糖控制，这些患者需要更多的胰岛素单位，这反过来又使体重控制更加困难。
