State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, 214122, P. R. China.
School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.
NPJ Biofilms Microbiomes. 2024 Jun 19;10(1):47. doi: 10.1038/s41522-024-00524-6.
Throughout the life span of a host, bifidobacteria have shown superior colonization and glycan abilities. Complex glycans, such as human milk oligosaccharides and plant glycans, that reach the colon are directly internalized by the transport system of bifidobacteria, cleaved into simple structures by extracellular glycosyl hydrolase, and transported to cells for fermentation. The glycan utilization of bifidobacteria introduces cross-feeding activities between bifidobacterial strains and other microbiota, which are influenced by host nutrition and regulate gut homeostasis. This review discusses bifidobacterial glycan utilization strategies, focusing on the cross-feeding involved in bifidobacteria and its potential health benefits. Furthermore, the impact of cross-feeding on the gut trophic niche of bifidobacteria and host health is also highlighted. This review provides novel insights into the interactions between microbe-microbe and host-microbe.
在宿主的整个生命周期中，双歧杆菌表现出优越的定植和聚糖能力。复杂的聚糖，如人乳寡糖和植物聚糖，到达结肠后被双歧杆菌的转运系统直接内化，被细胞外糖苷水解酶切割成简单的结构，并被转运到细胞中进行发酵。双歧杆菌的聚糖利用引入了双歧杆菌菌株和其他微生物群之间的交叉喂养活动，这些活动受到宿主营养的影响，并调节肠道内稳态。本综述讨论了双歧杆菌的聚糖利用策略，重点介绍了双歧杆菌之间的交叉喂养及其潜在的健康益处。此外，还强调了交叉喂养对双歧杆菌和宿主健康的肠道营养生态位的影响。本综述为微生物-微生物和宿主-微生物之间的相互作用提供了新的见解。
