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多物质所致肝毒性及支持性治疗的作用

Polysubstance-Induced Hepatotoxicity and the Role of Supportive Management.

作者信息

Qadir Nadim A, Stachler Luke, Reddy Anvit D, Diaz-Garcia Gerardo, Sottile Elisa

机构信息

Internal Medicine, University of Florida College of Medicine - Jacksonville, Jacksonville, USA.

出版信息

Cureus. 2024 May 20;16(5):e60649. doi: 10.7759/cureus.60649. eCollection 2024 May.

DOI:10.7759/cureus.60649
PMID:38899269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11185993/
Abstract

With the continued rise of polysubstance use throughout the country, it has been shown to affect a multitude of organ systems. Drug-induced liver injury (DILI) has been widely documented in its association with salicylates or acetaminophen and the utility of using N-acetylcysteine (NAC) for its hepatoprotective effects. However, DILI caused by illicit drug use and guideline-directed management has had little research. We present the case of a 29-year-old female who presented with altered mental status. She was found to have a concomitant liver injury and was treated supportively without the use of NAC, with gradual improvement.

摘要

随着全国多物质使用情况的持续增加，已表明其会影响多个器官系统。药物性肝损伤（DILI）与水杨酸盐或对乙酰氨基酚的关联以及使用N-乙酰半胱氨酸（NAC）的肝保护作用已被广泛记录。然而，由非法药物使用导致的DILI及其循证管理方面的研究很少。我们报告一例29岁女性患者，其出现精神状态改变。她被发现同时伴有肝损伤，在未使用NAC的情况下接受了支持性治疗，并逐渐好转。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/39f581f16600/cureus-0016-00000060649-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/98d766642a38/cureus-0016-00000060649-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/983132789dd7/cureus-0016-00000060649-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/c34660b4e71c/cureus-0016-00000060649-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/39f581f16600/cureus-0016-00000060649-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/98d766642a38/cureus-0016-00000060649-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/983132789dd7/cureus-0016-00000060649-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/c34660b4e71c/cureus-0016-00000060649-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cfa3/11185993/39f581f16600/cureus-0016-00000060649-i04.jpg

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本文引用的文献

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