Seo Suk Bae, Wan Jovian, Chan Lisa Kwin Wah, Lee Kar Wai Alvin, Kim Soo-Bin, Yi Kyu-Ho
SeoAhSong Dermatologic Clinic, Seoul, South Korea.
Asia-Pacific Aesthetic Academy, Hong Kong, Hong Kong.
Skin Res Technol. 2024 Jun;30(6):e13762. doi: 10.1111/srt.13762.
Acne vulgaris often results in permanent scars, with atrophic scars being the most common type and posing a significant therapeutic challenge due to their prevalence and impact on patients' quality of life. Various treatment options exist, including the use of poly-d,l-lactic acid delivered via different methods.
This study aimed to assess the efficacy and safety of poly-d,l-lactic acid delivered via laser-assisted needle-free microjet injection for treating atrophic scars.
Five Korean participants with atrophic facial scars were recruited. Poly-d,l-lactic acid solution was administered via the Mirajet system in five sessions, with clinical assessments conducted at baseline, before each session, and at 12-week and 22-week follow-ups. Outcome measures included the Global Aesthetic Improvement Scale and patient satisfaction scores.
Positive results were observed at the 12-week and 22-week follow-ups, with high patient satisfaction and improvements in atrophic scars and skin texture. Mild discomfort and transient side effects were reported, with no adverse events observed during the follow-up period.
Poly-d,l-lactic acid delivered by a laser-assisted needle-free microjet injector was judged to be effective for improving atrophic the facial area. Further research, particularly through randomized controlled trials, is needed to validate these findings and assess the longer-term safety and sustainability of outcomes.
寻常痤疮常导致永久性瘢痕，萎缩性瘢痕是最常见的类型，因其患病率以及对患者生活质量的影响，构成了重大的治疗挑战。存在多种治疗选择，包括通过不同方法递送的聚 -d，l- 乳酸。
本研究旨在评估通过激光辅助无针微喷射注射递送聚 -d，l- 乳酸治疗萎缩性瘢痕的疗效和安全性。
招募了 5 名患有面部萎缩性瘢痕的韩国参与者。通过 Mirajet 系统分 5 次给予聚 -d，l- 乳酸溶液，在基线、每次给药前以及 12 周和 22 周随访时进行临床评估。结果指标包括全球美学改善量表和患者满意度评分。
在 12 周和 22 周随访时观察到阳性结果，患者满意度高，萎缩性瘢痕和皮肤质地得到改善。报告了轻度不适和短暂的副作用，随访期间未观察到不良事件。
激光辅助无针微喷射注射器递送的聚 -d，l- 乳酸被判定对改善面部萎缩有效。需要进一步研究，特别是通过随机对照试验，以验证这些发现并评估结果的长期安全性和可持续性。
