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阿托品对人体中葡萄糖依赖性促胰岛素多肽诱导的胰岛素和胰多肽释放的影响。

Effects of atropine on GIP-induced insulin and pancreatic polypeptide release in man.

作者信息

Amland P F, Jorde R, Burhol P G, Giercksky K E

出版信息

Scand J Gastroenterol. 1985 Apr;20(3):321-4. doi: 10.3109/00365528509091658.

DOI:10.3109/00365528509091658
PMID:3890140
Abstract

Eight fasting students were given an infusion of porcine gastric inhibitory polypeptide (GIP) and glucose with or without atropine on two separate days. Mean serum insulin levels increased significantly and similarly on both occasions, indicating that both the glucose- and GIP-induced insulin release is unaffected by atropine. Plasma pancreatic polypeptide (PP) rose significantly during the GIP infusion on the day without atropine, suggesting a role for GIP in the intestinal phase of the PP release.

摘要

八名空腹学生在两个不同日期分别接受了猪胃抑制多肽(GIP)和葡萄糖的输注,其中一次添加了阿托品,另一次未添加。两次情况下,平均血清胰岛素水平均显著且相似地升高,表明葡萄糖和GIP诱导的胰岛素释放均不受阿托品影响。在未使用阿托品的那天,输注GIP期间血浆胰多肽(PP)显著升高,提示GIP在PP释放的肠期发挥作用。

相似文献

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Effects of atropine on GIP-induced insulin and pancreatic polypeptide release in man.阿托品对人体中葡萄糖依赖性促胰岛素多肽诱导的胰岛素和胰多肽释放的影响。
Scand J Gastroenterol. 1985 Apr;20(3):321-4. doi: 10.3109/00365528509091658.
2
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J Clin Invest. 1985 Sep;76(3):1174-81. doi: 10.1172/JCI112073.

引用本文的文献

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Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus.在2型糖尿病患者与非2型糖尿病患者中,对胆碱能输入的激素反应有所不同。
PLoS One. 2016 Jun 15;11(6):e0156852. doi: 10.1371/journal.pone.0156852. eCollection 2016.
2
The combination of GIP plus xenin-25 indirectly increases pancreatic polypeptide release in humans with and without type 2 diabetes mellitus.在患有和未患2型糖尿病的人群中,胃抑肽(GIP)与25肽外激素(xenin-25)联合使用可间接增加胰多肽的释放。
Regul Pept. 2013 Nov 10;187:42-50. doi: 10.1016/j.regpep.2013.10.003. Epub 2013 Oct 29.
3
Carbohydrate digestion and release of pancreatic polypeptide in health and diabetes mellitus.
健康与糖尿病状态下碳水化合物消化及胰多肽的释放
Gut. 1989 Sep;30(9):1279-84. doi: 10.1136/gut.30.9.1279.