Department of Neonatology, Children's University Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany.
Department of Neonatology, Children's University Hospital Regensburg (KUNO), Hospital St. Hedwig of the Order of St. John, University of Regensburg, Regensburg, Germany; Department of Paediatric Infectious Diseases and Vaccinology, University Children's Hospital Basel (UKBB) and University of Basel, Basel, Switzerland.
Vaccine. 2024 Oct 3;42(23):126050. doi: 10.1016/j.vaccine.2024.06.018. Epub 2024 Jun 19.
Recently, the first RSV vaccines have been approved, but vaccine hesitancy still poses great challenges to immunization programs.
To investigate this phenomenon in the context of the new RSV vaccines and an increased virus activity in 2022/23, we assessed parental knowledge and attitudes towards general childhood and RSV vaccines.
Parents of infants from 0-36 months completed an online questionnaire on demographics, socio-economic status, mental well-being, knowledge on RSV and perceptions of disease, attitudes to general childhood and RSV vaccines. The survey was conducted from February-June 2023 in the region of Regensburg, Germany. We compared continuous or categorical data with two-sided t-tests or Chi-square tests, respectively. Linear and logistic regression models were used to adjust for confounders.
From 191 survey participants, 84 % had never refused any recommended vaccination and 91 % trusted their paediatrician's information. 11 % felt that children should have fewer vaccinations or rather get over the illness. Parents who were supportive or undecided about RSV vaccination were less likely to be vaccine hesitant in general (OR 0.03, p < 0.001; OR 0.13, p = 0.003). 58 % reported to have basic or good knowledge on RSV, correlating with a higher socioeconomic index (p = 0.049). 24 % were undecided about RSV immunization, while all parents rated its benefit high in the child's first year of life. Parents who refused RSV vaccination were less concerned about the infection compared to vaccine supporters (OR 0.44, p < 0.001). Parents with previously hospitalized (OR 3.88, p = 0.017) or preterm born children (OR 5.12, p = 0.026) were generally more concerned.
Many factors influence parental decision-making leading to three main groups of attitudes: vaccine acceptors, refusers and hesitant but accessible parents. They (24%) represent the "target group" to increase vaccine uptake. Information on the vaccine-preventable disease reduces vaccine hesitancy, underlining the importance of healthcare professionals who remain an important source of trust.
最近，首批 RSV 疫苗已获得批准，但疫苗犹豫仍然给免疫计划带来了巨大挑战。
鉴于新的 RSV 疫苗和 2022/23 年病毒活动增加的情况，我们评估了父母对一般儿童和 RSV 疫苗的知识和态度。
0-36 个月婴儿的父母完成了一份关于人口统计学、社会经济地位、心理健康、对 RSV 的认识和对疾病的看法、对一般儿童和 RSV 疫苗的态度的在线问卷。该调查于 2023 年 2 月至 6 月在德国雷根斯堡地区进行。我们分别使用双侧 t 检验或卡方检验比较连续或分类数据。使用线性和逻辑回归模型调整混杂因素。
在 191 名调查参与者中，84%的人从未拒绝过任何推荐的疫苗接种，91%的人信任他们的儿科医生的信息。11%的人认为孩子应该接种更少的疫苗或从疾病中康复。支持或未决定 RSV 疫苗接种的父母不太可能对一般疫苗接种犹豫不决（OR 0.03，p<0.001；OR 0.13，p=0.003）。58%的人报告对 RSV 有基本或良好的认识，与较高的社会经济指数相关（p=0.049）。24%的人对 RSV 免疫犹豫不决，而所有父母都认为 RSV 疫苗在孩子的第一年非常有益。与疫苗支持者相比，拒绝 RSV 疫苗接种的父母对感染的关注度较低（OR 0.44，p<0.001）。有住院（OR 3.88，p=0.017）或早产（OR 5.12，p=0.026）儿童的父母通常更关注 RSV 感染。
许多因素影响父母的决策，导致出现三种主要的态度群体：疫苗接受者、拒绝者和犹豫不决但可接触的父母。他们（24%）是提高疫苗接种率的“目标群体”。有关疫苗可预防疾病的信息可降低疫苗犹豫情绪，凸显了医疗保健专业人员的重要性，他们仍然是信任的重要来源。
