Williams J W, Peters T G, Vera S R, Britt L G, van Voorst S J, Haggitt R C
Transplantation. 1985 Jun;39(6):589-96. doi: 10.1097/00007890-198506000-00003.
Patients undergoing orthotopic hepatic transplantation were studied with routinely available liver function studies and serial hepatic biopsies. Rejection was diagnosed only if confirmed histologically. Cyclosporine and a rapidly decreasing dose of corticosteroids were used for immunosuppression. Hepatic dysfunction suggesting rejection was seen in 22 instances, but acute rejection was diagnosed histologically in only 6 patients. The liver function studies used in these patients did not accurately distinguish rejection from other causes of hepatic dysfunction. We conclude that liver biopsy as performed in these patients is an accurate and safe means of assessing the adequacy of immunosuppression and minimizing the use of high dose corticosteroids.
对接受原位肝移植的患者进行了常规肝功能检查和系列肝脏活检。仅在组织学确诊时才诊断为排斥反应。使用环孢素和快速递减剂量的皮质类固醇进行免疫抑制。22例出现提示排斥反应的肝功能障碍，但仅6例患者经组织学诊断为急性排斥反应。这些患者所使用的肝功能检查未能准确区分排斥反应与肝功能障碍的其他原因。我们得出结论，对这些患者进行的肝脏活检是评估免疫抑制是否充分以及尽量减少高剂量皮质类固醇使用的准确且安全的方法。
