Arora Kunal, Singh Amit S, Bedi Rajeev, Dang Ketan, Kaur Arunjeet
Intensive Care Unit, Fortis Hospital, Mohali, Punjab, India.
Department of Neurology, Fortis Hospital, Mohali, Punjab, India.
Ann Indian Acad Neurol. 2024 May 1;27(3):313-315. doi: 10.4103/aian.aian_22_24. Epub 2024 Jun 20.
Although chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world, neurologic complications arising from direct leukemic involvement of the nervous system are reported in only 1% of patients with CLL. Ocular involvement in CLL, direct or indirect, is less known and exceptionally rare. This case involves a 63-year-old female with CLL undergoing chemotherapy for a year, who recently presented with unusual eye movements in the horizontal plane (ocular flutter), resting and intentional tremors in the right upper and lower limbs, and intermittent jaw movements. With no established protocol for CLL with central nervous system involvement, collecting case data becomes crucial for determining optimal treatment and diagnostic approaches early on.
尽管慢性淋巴细胞白血病（CLL）是西方世界最常见的白血病，但仅1%的CLL患者报告有因白血病直接累及神经系统而出现的神经并发症。CLL的眼部累及，无论是直接还是间接的，都鲜为人知且极为罕见。该病例涉及一名63岁患有CLL的女性，她接受了一年的化疗，最近出现了水平面异常眼球运动（眼球扑动）、右上肢和下肢静息性和意向性震颤以及间歇性下颌运动。由于没有针对CLL合并中枢神经系统受累的既定方案，收集病例数据对于尽早确定最佳治疗和诊断方法至关重要。
