Setor de Ortopedia e Traumatologia, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brasil.
Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso Do Sul - UFMS, Campo Grande, MS, Brasil.
Cell Tissue Bank. 2024 Sep;25(3):831-838. doi: 10.1007/s10561-024-10141-4. Epub 2024 Jun 21.
The aim of this study was to evaluate the effect of adipose-derived stem cells (ADSCs) in the treatment of acute rupture of the Achilles tendon. It was a cross-sectional study involving 15 patients. Patients were randomly divided: group 1-rupture; group 2-suture; group 3-rupture + ADSCs. In the AOFAS score, the score was higher in group 3 with a significant difference. In the ATRS score, the score was higher in groups 2 and 3, also with a significant difference. As for the ultrasound score, there was a significant difference between the experimental groups in relation to this score, however, in the multiple comparisons test, comparing two groups at a time, it was possible to observe a significant difference of the experimental groups. It can be concluded that cell therapy in this condition may be a treatment option due to tissue regeneration and significant recovery of function.
本研究旨在评估脂肪源性干细胞（ADSCs）在治疗急性跟腱断裂中的作用。这是一项涉及 15 名患者的横断面研究。患者被随机分为三组：组 1-断裂；组 2-缝合；组 3-断裂+ADSCs。在 AOFAS 评分中，组 3 的评分更高，差异具有统计学意义。在 ATRS 评分中，组 2 和组 3 的评分更高，差异也具有统计学意义。至于超声评分，实验组之间的差异具有统计学意义，但在多重比较检验中，每次比较两组时，实验组之间存在显著差异。可以得出结论，由于组织再生和功能的显著恢复，这种情况下的细胞治疗可能是一种治疗选择。
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