通过纳米孔测序进行内部 mRNA 2'-O-甲基化图谱绘制及其对 mRNA 稳定性和癌症作用的影响。
Internal mRNA 2'-O-methyl mapping by nanopore sequencing and consequence on mRNA stability and role in cancer.
机构信息
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA.
出版信息
Mol Cell. 2024 Jun 20;84(12):2215-2217. doi: 10.1016/j.molcel.2024.05.020.
PMID:38906112
Abstract
In this issue, Li et al. report internal mRNA 2'-O-methyl (Nm) modification mapping by nanopore sequencing and the effect of Nm on mRNA stability and cancer cell progression.
摘要
在本期中，李等人通过纳米孔测序报告了内部 mRNA 2'-O-甲基 (Nm) 修饰图谱，以及 Nm 对 mRNA 稳定性和癌细胞进展的影响。
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