Bagheri Minoo, Tanriverdi Kahraman, Iafrati Mark D, Mosley Jonathan D, Freedman Jane E, Ferguson Jane F
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Department of Vascular Surgery, Vanderbilt University Medical Center, United States of America.
Metabolism. 2024 Sep;158:155955. doi: 10.1016/j.metabol.2024.155955. Epub 2024 Jun 19.
Bariatric surgery improves metabolic health, but the underlying mechanisms are not fully understood. We analyzed the effects of two types of bariatric surgery, sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB), on the plasma metabolome and lipidome.
We characterized the plasma metabolome (1268 metabolites) and lipidome (953 lipids) pre-operatively and at 3 and 12 months post-operatively in 104 obese adults who were previously recruited to a prospective cohort of bariatric surgery. The metabolomic and lipidomic responses to bariatric surgery over time were analyzed using multivariable linear mixed-effects models.
There were significant changes in multiple metabolites and lipids, including rapid early changes in amino acid and peptide metabolites, including decreases in branched-chain amino acids (BCAAs), aromatic AAs, alanine and aspartate, and increases in glycine, serine, arginine and citrulline. There were also significant decreases in many triglyceride species, with increases in phosphatidylcholines and phosphatidylethanolamines. There were significant changes in metabolites related to energy metabolism that were apparent only after 12 months. We observed differences by bariatric surgery type in the changes in a small number of primary and secondary bile acids, including glycohyocholate and glyco-beta-muricholate.
Our findings highlight the comprehensive changes in metabolites and lipids that occur over the 12 months following bariatric surgery. While both SG and RYGB caused profound changes in the metabolome and lipidome, RYGB was characterized by greater increases in bile acids following surgery.
减肥手术可改善代谢健康，但其潜在机制尚未完全明确。我们分析了两种减肥手术，即袖状胃切除术（SG）和Roux-en-Y胃旁路术（RYGB）对血浆代谢组和脂质组的影响。
我们对104名肥胖成年人术前、术后3个月和12个月时的血浆代谢组（1268种代谢物）和脂质组（953种脂质）进行了表征，这些人之前被纳入一个减肥手术前瞻性队列。使用多变量线性混合效应模型分析了减肥手术随时间的代谢组学和脂质组学反应。
多种代谢物和脂质有显著变化，包括氨基酸和肽类代谢物的快速早期变化，如支链氨基酸（BCAAs）、芳香族氨基酸、丙氨酸和天冬氨酸减少，而甘氨酸、丝氨酸、精氨酸和瓜氨酸增加。许多甘油三酯种类也显著减少，同时磷脂酰胆碱和磷脂酰乙醇胺增加。与能量代谢相关的代谢物在术后12个月才出现显著变化。我们观察到，在少数初级和次级胆汁酸的变化方面，不同类型的减肥手术存在差异，包括甘氨鹅脱氧胆酸盐和甘氨-β-鼠胆酸盐。
我们的研究结果突出了减肥手术后12个月内代谢物和脂质发生的全面变化。虽然SG和RYGB都引起了代谢组和脂质组的深刻变化，但RYGB的特点是术后胆汁酸增加幅度更大。
