Endocrine & Metabolic Research, Unit for Multidisciplinary Research in Biomedicine (UMIB), University of Porto, Porto, Portugal.
Department of Anatomy, School of Medicine and Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal.
Rev Endocr Metab Disord. 2022 Jun;23(3):503-519. doi: 10.1007/s11154-021-09695-5. Epub 2021 Dec 2.
Metabolomics emerged as an important tool to gain insights on how the body responds to therapeutic interventions. Bariatric surgery is the most effective treatment for severe obesity and obesity-related co-morbidities. Our aim was to conduct a systematic review of the available data on metabolomics profiles that characterize patients submitted to different bariatric surgery procedures, which could be useful to predict clinical outcomes including weight loss and type 2 diabetes remission. For that, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses - PRISMA guidelines were followed. Data from forty-seven original study reports addressing metabolomics profiles induced by bariatric surgery that met eligibility criteria were compiled and summarized. Amino acids, lipids, energy-related and gut microbiota-related were the metabolite classes most influenced by bariatric surgery. Among these, higher pre-operative levels of specific lipids including phospholipids, long-chain fatty acids and bile acids were associated with post-operative T2D remission. As conclusion, metabolite profiling could become a useful tool to predict long term response to different bariatric surgery procedures, allowing more personalized interventions and improved healthcare resources allocation.
代谢组学作为一种重要的工具，可以深入了解身体对治疗干预的反应。减重手术是治疗严重肥胖和肥胖相关合并症最有效的方法。我们的目的是对不同减重手术程序诱导的代谢组学特征的现有数据进行系统综述，这可能有助于预测包括体重减轻和 2 型糖尿病缓解在内的临床结果。为此，我们遵循了系统评价和荟萃分析的首选报告项目 - PRISMA 指南。编译并总结了符合入选标准的 47 项原始研究报告中涉及到的代谢组学特征的数据。氨基酸、脂质、与能量相关和与肠道微生物群相关的代谢物是受减重手术影响最大的代谢物类别。其中，术前特定脂质（包括磷脂、长链脂肪酸和胆汁酸）水平较高与术后 2 型糖尿病缓解相关。总之，代谢组学分析可能成为预测不同减重手术程序长期反应的有用工具，从而实现更个性化的干预和改善医疗资源分配。
