Antimicrobial Resistance and Infectious Diseases (AMRID) Research Laboratory, Harry Butler Institute, Murdoch University, Perth, Australia.
Antimicrobial Resistance and Infectious Diseases (AMRID) Research Laboratory, Harry Butler Institute, Murdoch University, Perth, Australia; Department of Microbiology, PathWest Laboratory Medicine WA, Fiona Stanley Hospital, Perth, Australia.
Int J Antimicrob Agents. 2024 Sep;64(3):107251. doi: 10.1016/j.ijantimicag.2024.107251. Epub 2024 Jun 19.
Antimicrobial resistance (AMR) has emerged as a critical global health challenge. However, the significance of AMR is not limited to humans and domestic animals but extends to wildlife and the environment. Based on the analysis of > 200 peer-reviewed papers, this review provides comprehensive and current insights into the detection of clinically significant antimicrobial resistant bacteria and resistance genes in wild mammals, birds and reptiles worldwide. The review also examines the overlooked roles of wildlife in AMR emergence and transmission. In wildlife, AMR is potentially driven by anthropogenic activity, agricultural and environmental factors, and natural evolution. This review highlights the significance of AMR surveillance in wildlife, identifies species and geographical foci and gaps, and demonstrates the value of multifaceted One Health strategies if further escalation of AMR globally is to be curtailed.
抗生素耐药性（AMR）已经成为一个严峻的全球健康挑战。然而，AMR 的重要性不仅局限于人类和家养动物，还延伸到了野生动物和环境。基于对>200 篇同行评议论文的分析，本综述全面而及时地介绍了全球范围内野生哺乳动物、鸟类和爬行动物中临床相关的抗微生物耐药细菌和耐药基因的检测。本综述还探讨了野生动物在 AMR 出现和传播中被忽视的作用。在野生动物中，AMR 可能是由人为活动、农业和环境因素以及自然进化驱动的。本综述强调了在野生动物中进行 AMR 监测的重要性，确定了具有重要意义的物种和地理重点及差距，并展示了如果要遏制 AMR 在全球范围内的进一步升级，多方面的“同一健康”策略的价值。
