Hock Louise, Walczak Cécile, Mosser Juliette, Ragimbeau Catherine, Cauchie Henry-Michel
Environmental Research and Innovation (ERIN) Department, Luxembourg Institute of Science and Technology (LIST), 41 Rue du Brill, L-4422 Belvaux, Luxembourg.
Epidemiology and Microbial Genomics, Laboratoire National de Santé (LNS), 1 Rue Louis Rech, L-3555 Dudelange, Luxembourg.
Microorganisms. 2024 Aug 8;12(8):1621. doi: 10.3390/microorganisms12081621.
Antimicrobial resistance (AMR) is a growing global health challenge, compromising bacterial infection treatments and necessitating robust surveillance and mitigation strategies. The overuse of antimicrobials in humans and farm animals has made them hotspots for AMR. However, the spread of AMR genes in wildlife and the environment represents an additional challenge, turning these areas into new AMR hotspots. Among the AMR bacteria considered to be of high concern for public health, has been the leading cause of foodborne infections in the European Union since 2005. This study examines the prevalence of AMR genes and virulence factors in isolates from wild birds and surface waters in Luxembourg. The findings reveal a significant prevalence of resistant strains, with 12% of from wild birds and 37% of from surface waters carrying resistance genes, mainly against key antibiotics like quinolones and tetracycline. This study underscores the crucial role of the environment in the spread of AMR bacteria and genes, highlighting the urgent need for enhanced surveillance and control measures to curb AMR in wildlife and environmental reservoirs and reduce transmission risks to humans. This research supports One Health approaches to tackling antimicrobial resistance and protecting human, animal, and environmental health.
抗菌药物耐药性（AMR）是一个日益严峻的全球卫生挑战，它危及细菌感染的治疗，因此需要强有力的监测和缓解策略。在人类和农场动物中过度使用抗菌药物已使它们成为AMR的热点地区。然而，AMR基因在野生动物和环境中的传播带来了额外的挑战，使这些地区成为新的AMR热点。在被认为对公共卫生高度关注的AMR细菌中，自2005年以来一直是欧盟食源性感染的主要原因。本研究调查了卢森堡野生鸟类和地表水中分离株中AMR基因和毒力因子的流行情况。研究结果显示，耐药菌株的流行率很高，野生鸟类分离株中有12%以及地表水中分离株中有37%携带耐药基因，主要是对喹诺酮类和四环素等关键抗生素的耐药基因。这项研究强调了环境在AMR细菌和基因传播中的关键作用，突出了迫切需要加强监测和控制措施，以遏制野生动物和环境储库中的AMR，并降低向人类传播的风险。这项研究支持采用“同一健康”方法来应对抗菌药物耐药性并保护人类、动物和环境健康。
