氨曲南治疗由b型流感嗜血杆菌和大肠杆菌K1引起的实验性脑膜炎。
Aztreonam therapy in experimental meningitis due to Haemophilus influenzae type b and Escherichia coli K1.
作者信息
McCracken G H, Sakata Y, Olsen K D
出版信息
Antimicrob Agents Chemother. 1985 Apr;27(4):655-6. doi: 10.1128/AAC.27.4.655.
Abstract
The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.
摘要
在实验性b型流感嗜血杆菌和大肠杆菌K1脑膜炎中，氨曲南在脑脊液中的渗透率分别为7%至15%和9%至25%。单剂量和持续输注给药后，氨曲南可有效减少脑脊液中的细菌数量，脑脊液中针对两种脑膜病原体的杀菌效价中位数均为1:32。
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