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2
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1
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Antimicrob Agents Chemother. 1982 Mar;21(3):390-2. doi: 10.1128/AAC.21.3.390.
2
Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.氨曲南（SQ 26,776），一种对需氧革兰氏阴性菌有特效的合成单环β-内酰胺抗生素。
Antimicrob Agents Chemother. 1982 Jan;21(1):85-92. doi: 10.1128/AAC.21.1.85.
3
Comparative in vitro study of SQ26,776.SQ26,776的体外对比研究。
Antimicrob Agents Chemother. 1982 Feb;21(2):294-8. doi: 10.1128/AAC.21.2.294.
4
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Antimicrob Agents Chemother. 1984 Aug;26(2):196-9. doi: 10.1128/AAC.26.2.196.
5
Pharmacokinetics and bacteriological efficacy of moxalactam (LY127935), netilmicin, and ampicillin in experimental gram-negative enteric bacillary meningitis.羟羧氧酰胺菌素（LY127935）、奈替米星和氨苄西林在实验性革兰阴性肠道杆菌性脑膜炎中的药代动力学及细菌学疗效
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6
Pharmacokinetics and bacteriological efficacy of mezlocillin in experimental Escherichia coli and Listeria monocytogenes meningitis.美洛西林在实验性大肠杆菌和单核细胞增生李斯特菌脑膜炎中的药代动力学及细菌学疗效
Antimicrob Agents Chemother. 1984 Apr;25(4):427-32. doi: 10.1128/AAC.25.4.427.
7
Evaluation of aztreonam in experimental bacterial meningitis and cerebritis.氨曲南在实验性细菌性脑膜炎和脑脓肿中的评估。
Antimicrob Agents Chemother. 1983 Nov;24(5):682-8. doi: 10.1128/AAC.24.5.682.
8
Pharmacokinetics and bacteriological effect of ceftazidime in experimental Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli meningitis.头孢他啶在实验性肺炎链球菌、流感嗜血杆菌和大肠杆菌脑膜炎中的药代动力学及细菌学效应
Antimicrob Agents Chemother. 1983 Feb;23(2):213-7. doi: 10.1128/AAC.23.2.213.
9
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10
Pharmacokinetics and bacteriological efficacy of cefoperazone, ceftriaxone, and moxalactam in experimental Streptococcus pneumoniae and Haemophilus influenzae meningitis.头孢哌酮、头孢曲松和拉氧头孢在实验性肺炎链球菌和流感嗜血杆菌脑膜炎中的药代动力学及细菌学疗效
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氨曲南治疗由b型流感嗜血杆菌和大肠杆菌K1引起的实验性脑膜炎。

Aztreonam therapy in experimental meningitis due to Haemophilus influenzae type b and Escherichia coli K1.

作者信息

McCracken G H, Sakata Y, Olsen K D

出版信息

Antimicrob Agents Chemother. 1985 Apr;27(4):655-6. doi: 10.1128/AAC.27.4.655.

DOI:10.1128/AAC.27.4.655
PMID:3890733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180117/
Abstract

The penetration of aztreonam into cerebrospinal fluid was 7 to 15% and 9 to 25%, respectively, in experimental Haemophilus influenzae type b and Escherichia coli K1 meningitis. Aztreonam was effective in reducing the number of organisms in cerebrospinal fluid after single-dose and continuous infusion administration, and the median bactericidal titers in cerebrospinal fluid were 1:32 against both meningeal pathogens.

摘要

在实验性b型流感嗜血杆菌和大肠杆菌K1脑膜炎中，氨曲南在脑脊液中的渗透率分别为7%至15%和9%至25%。单剂量和持续输注给药后，氨曲南可有效减少脑脊液中的细菌数量，脑脊液中针对两种脑膜病原体的杀菌效价中位数均为1:32。