亚胺培南、头孢他啶和头孢曲松在由对氨苄西林和氯霉素耐药的b型流感嗜血杆菌菌株引起的实验性脑膜炎中的药代动力学及治疗效果
Pharmacokinetics and therapeutic efficacy of imipenem, ceftazidime, and ceftriaxone in experimental meningitis due to an ampicillin- and chloramphenicol-resistant strain of Haemophilus influenzae type b.
作者信息
Sakata Y, McCracken G H, Thomas M L, Olsen K D
出版信息
Antimicrob Agents Chemother. 1984 Jan;25(1):29-32. doi: 10.1128/AAC.25.1.29.
Abstract
The pharmacokinetics and therapeutic efficacy of imipenem, ceftazidime, and ceftriaxone were compared with those of ampicillin and chloramphenicol in rabbits with experimental meningitis due to an ampicillin- and chloramphenicol-resistant strain of Haemophilus influenzae type b. The mean bacterial colony counts in cerebrospinal fluid were reduced by 49% (-1.85 log10 CFU/ml), 92% (-3.37 log10 CFU/ml), and 92% (-4.30 log10 CFU/ml) after a single dose of imipenem, ceftazidime, and ceftriaxone, respectively. The median peak cerebrospinal fluid bactericidal titers against this multiply resistant strain of H. influenzae were 1:4 for thienamycin, 1:16 for ceftazidime, and 1:256 for ceftriaxone. By contrast, no bactericidal activity was observed in cerebrospinal fluid and the mean concentrations of H. influenzae were either unchanged or slightly increased in animals treated with ampicillin or chloramphenicol.
摘要
在患有由对氨苄西林和氯霉素耐药的b型流感嗜血杆菌菌株引起的实验性脑膜炎的兔子中，比较了亚胺培南、头孢他啶和头孢曲松与氨苄西林和氯霉素的药代动力学及治疗效果。单剂量给予亚胺培南、头孢他啶和头孢曲松后，脑脊液中的平均细菌菌落计数分别降低了49%（-1.85 log10 CFU/ml）、92%（-3.37 log10 CFU/ml）和92%（-4.30 log10 CFU/ml）。针对这种多重耐药的流感嗜血杆菌菌株，脑脊液杀菌效价的中位数，硫霉素为1:4，头孢他啶为1:16，头孢曲松为1:256。相比之下，在用氨苄西林或氯霉素治疗的动物中，脑脊液中未观察到杀菌活性，流感嗜血杆菌的平均浓度要么未改变，要么略有增加。
相似文献
1
Pharmacokinetics and therapeutic efficacy of imipenem, ceftazidime, and ceftriaxone in experimental meningitis due to an ampicillin- and chloramphenicol-resistant strain of Haemophilus influenzae type b.亚胺培南、头孢他啶和头孢曲松在由对氨苄西林和氯霉素耐药的b型流感嗜血杆菌菌株引起的实验性脑膜炎中的药代动力学及治疗效果
Antimicrob Agents Chemother. 1984 Jan;25(1):29-32. doi: 10.1128/AAC.25.1.29.
2
Pharmacokinetics and bacteriological effect of ceftazidime in experimental Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli meningitis.头孢他啶在实验性肺炎链球菌、流感嗜血杆菌和大肠杆菌脑膜炎中的药代动力学及细菌学效应
Antimicrob Agents Chemother. 1983 Feb;23(2):213-7. doi: 10.1128/AAC.23.2.213.
3
In-vitro activity of imipenem against 100 strains of serotype b and nontypable Haemophilus influenzae, including strains resistant to ampicillin, chloramphenicol or both.亚胺培南对100株b型和不可分型流感嗜血杆菌的体外活性，包括对氨苄西林、氯霉素或两者均耐药的菌株。
J Antimicrob Chemother. 1985 Nov;16(5):549-54. doi: 10.1093/jac/16.5.549.
4
Evaluation of ceftazidime, ampicillin and chloramphenicol in experimental Haemophilus influenzae type b meningitis.
J Antimicrob Chemother. 1984 May;13(5):437-45. doi: 10.1093/jac/13.5.437.
5
Meningitis due to Haemophilus influenzae type b resistant to both ampicillin and chloramphenicol.由对氨苄西林和氯霉素均耐药的b型流感嗜血杆菌引起的脑膜炎。
Pediatrics. 1980 Jul;66(1):14-6.
6
Meningitis and septicaemia due to a multiply resistant strain of Haemophilus influenzae type b.由b型流感嗜血杆菌多重耐药菌株引起的脑膜炎和败血症。
J Infect. 1987 Jan;14(1):61-5. doi: 10.1016/s0163-4453(87)90860-7.
7
Pharmacokinetics and bacteriological efficacy of cefoperazone, ceftriaxone, and moxalactam in experimental Streptococcus pneumoniae and Haemophilus influenzae meningitis.头孢哌酮、头孢曲松和拉氧头孢在实验性肺炎链球菌和流感嗜血杆菌脑膜炎中的药代动力学及细菌学疗效
Antimicrob Agents Chemother. 1982 Feb;21(2):262-7. doi: 10.1128/AAC.21.2.262.
8
[Haemophilus influenzae type b meningitis resistant to ampicillin and chloramphenicol treated with moxalactam].用羟羧氧酰胺菌素治疗的对氨苄西林和氯霉素耐药的b型流感嗜血杆菌脑膜炎
An Esp Pediatr. 1983 May;18(5):410-1.
9
Activities of newer beta-lactam antibiotics against ampicillin, chloramphenicol, or multiply-resistant Haemophilus influenzae.新型β-内酰胺类抗生素对氨苄西林、氯霉素或多重耐药流感嗜血杆菌的活性。
Diagn Microbiol Infect Dis. 1984 Sep;2(4):333-7. doi: 10.1016/0732-8893(84)90065-8.
10
Haemophilus influenzae type b meningitis resistant to ampicillin and chloramphenicol.对氨苄西林和氯霉素耐药的b型流感嗜血杆菌脑膜炎
Arch Dis Child. 1986 Jul;61(7):691-2. doi: 10.1136/adc.61.7.691.
引用本文的文献
1
Intravitreal vancomycin and amikacin versus intravenous imipenem in the treatment of experimental Staphylococcus aureus endophthalmitis.玻璃体内注射万古霉素和阿米卡星与静脉注射亚胺培南治疗实验性金黄色葡萄球菌性眼内炎的比较。
Graefes Arch Clin Exp Ophthalmol. 2004 Apr;242(4):313-20. doi: 10.1007/s00417-003-0767-9. Epub 2004 Feb 24.
2
Intravenous treatment of experimental Staphylococcus aureus endophthalmitis: imipenem versus the combination of ceftazidime and amikacin.实验性金黄色葡萄球菌性眼内炎的静脉治疗：亚胺培南与头孢他啶和阿米卡星联合用药的对比
Graefes Arch Clin Exp Ophthalmol. 2003 Dec;241(12):1029-36. doi: 10.1007/s00417-003-0768-8. Epub 2003 Nov 14.
3
Pharmacokinetics and bacteriological efficacy of mezlocillin in experimental Escherichia coli and Listeria monocytogenes meningitis.美洛西林在实验性大肠杆菌和单核细胞增生李斯特菌脑膜炎中的药代动力学及细菌学疗效
Antimicrob Agents Chemother. 1984 Apr;25(4):427-32. doi: 10.1128/AAC.25.4.427.
4
Aztreonam therapy in experimental meningitis due to Haemophilus influenzae type b and Escherichia coli K1.氨曲南治疗由b型流感嗜血杆菌和大肠杆菌K1引起的实验性脑膜炎。
Antimicrob Agents Chemother. 1985 Apr;27(4):655-6. doi: 10.1128/AAC.27.4.655.
5
In vitro susceptibilities of Haemophilus influenzae isolates from a Veterans Administration Medical Center.来自一家退伍军人管理局医疗中心的流感嗜血杆菌分离株的体外药敏试验结果
Med Microbiol Immunol. 1985;173(6):303-9. doi: 10.1007/BF02125034.
6
Antimicrobial therapy of experimental meningitis caused by Streptococcus pneumoniae strains with different susceptibilities to penicillin.对青霉素敏感性不同的肺炎链球菌菌株所致实验性脑膜炎的抗菌治疗
Antimicrob Agents Chemother. 1985 Feb;27(2):141-5. doi: 10.1128/AAC.27.2.141.
7
Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.亚胺培南/西司他丁。对其抗菌活性、药代动力学特性及治疗效果的综述。
Drugs. 1987 Mar;33(3):183-241. doi: 10.2165/00003495-198733030-00001.
8
The clinical relevance of protein binding and tissue concentrations in antimicrobial therapy.
Clin Pharmacokinet. 1986 Nov-Dec;11(6):470-82. doi: 10.2165/00003088-198611060-00004.
9
Cephalosporins in the treatment of meningitis.头孢菌素类药物在脑膜炎治疗中的应用
Drugs. 1987;34 Suppl 2:135-53. doi: 10.2165/00003495-198700342-00011.
10
[Rational parameters in the treatment of bacterial meningitis with modern cephalosporins].[现代头孢菌素治疗细菌性脑膜炎的合理参数]
Infection. 1987;15 Suppl 4:S214-9. doi: 10.1007/BF01645874.
本文引用的文献
1
Antibiotic therapy of bacterial meningitis: lessons we've learned.细菌性脑膜炎的抗生素治疗：我们学到的经验教训。
Am J Med. 1981 Oct;71(4):507-10. doi: 10.1016/0002-9343(81)90191-1.
2
Susceptibility of multiply antibiotic-resistant pneumococci to the new beta-lactam drugs and rosaramicin.多重耐药肺炎球菌对新型β-内酰胺类药物和罗沙米星的敏感性
Antimicrob Agents Chemother. 1981 Apr;19(4):675-7. doi: 10.1128/AAC.19.4.675.
3
Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis.N-甲酰亚胺硫霉素在实验性大肠杆菌脑膜炎中的药代动力学及细菌学疗效
Antimicrob Agents Chemother. 1982 Mar;21(3):390-2. doi: 10.1128/AAC.21.3.390.
4
Meningitis due to Haemophilus influenzae type b resistant to ampicillin and chloramphenicol.由对氨苄西林和氯霉素耐药的b型流感嗜血杆菌引起的脑膜炎。
J Pediatr. 1980 Sep;97(3):421-4. doi: 10.1016/s0022-3476(80)80193-4.
5
Meningitis due to Haemophilus influenzae type b resistant to both ampicillin and chloramphenicol.由对氨苄西林和氯霉素均耐药的b型流感嗜血杆菌引起的脑膜炎。
Pediatrics. 1980 Jul;66(1):14-6.
6
Comparison of cotrimoxazole, ampicillin, and chloramphenicol in treatment of experimental Haemophilus influenzae type B meningitis.复方新诺明、氨苄青霉素和氯霉素治疗实验性B型流感嗜血杆菌脑膜炎的比较。
Antimicrob Agents Chemother. 1980 Jan;17(1):43-8. doi: 10.1128/AAC.17.1.43.
7
Susceptibility of pneumococci to 14 beta-lactam agents: comparison of strains resistant, intermediate-resistant, and susceptible to penicillin.肺炎球菌对14种β-内酰胺类药物的敏感性：青霉素耐药、中介耐药和敏感菌株的比较。
Antimicrob Agents Chemother. 1981 Aug;20(2):204-7. doi: 10.1128/AAC.20.2.204.
8
Antibiotic resistance in Haemophilus influenzae.流感嗜血杆菌中的抗生素耐药性。
Pediatr Infect Dis. 1983 Sep-Oct;2(5):352-5. doi: 10.1097/00006454-198309000-00003.
9
Pharmacokinetics and bacteriological effect of ceftazidime in experimental Streptococcus pneumoniae, Haemophilus influenzae, and Escherichia coli meningitis.头孢他啶在实验性肺炎链球菌、流感嗜血杆菌和大肠杆菌脑膜炎中的药代动力学及细菌学效应
Antimicrob Agents Chemother. 1983 Feb;23(2):213-7. doi: 10.1128/AAC.23.2.213.
10
Pharmacokinetics and bacteriologic efficacy of moxalactam, cefotaxime, cefoperazone, and rocephin in experimental bacterial meningitis.羟羧氧酰胺菌素、头孢噻肟、头孢哌酮和头孢曲松在实验性细菌性脑膜炎中的药代动力学及细菌学疗效
J Infect Dis. 1981 Feb;143(2):156-63. doi: 10.1093/infdis/143.2.156.
Zotero 插件