Winkelmann R K, Peters M S
Arch Dermatol. 1985 Jun;121(6):753-5. doi: 10.1001/archderm.121.6.753.
Fourteen biopsy specimens from ten patients with atypical fibroxanthoma were studied with the peroxidase-antiperoxidase method for binding of S-100 antibody. Six specimens from four patients were minimally positive. The S-100-positive cells were observed in greatest concentrations at the periphery of the lesions and were associated with perivascular inflammatory cells. By this method, it appears that there is not a Langerhans' cell type of atypical fibroxanthoma. The S-100 antibody can help differentiate desmoplastic juvenile melanoma and malignant melanoma from atypical fibroxanthoma.
对10例非典型纤维黄色瘤患者的14份活检标本采用过氧化物酶-抗过氧化物酶法研究S-100抗体的结合情况。4例患者的6份标本呈弱阳性。S-100阳性细胞在病变周边浓度最高，且与血管周围炎性细胞相关。通过这种方法，似乎不存在朗格汉斯细胞型非典型纤维黄色瘤。S-100抗体有助于将促纤维增生性幼年黑素瘤和恶性黑素瘤与非典型纤维黄色瘤区分开来。
