Department of Central Hospital of Tujia and Miao Autonomous Prefecture, Hubei University of Medicine, Shiyan, Hubei Province, China.
Department of Cardiology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China; Institute of Myocardial Injury and Repair, Wuhan University, Wuhan, Hubei Province, China.
Biomol Biomed. 2024 Oct 17;24(6):1726-1734. doi: 10.17305/bb.2024.10747.
This study aims to analyze the correlation between Systemic Inflammatory Response Index (SIRI) and the severity of coronary artery stenosis in patients with coronary heart disease (CHD). It also aims to assess the predictive value of SIRI for the severity of coronary artery stenosis. A total of 2990 patients who underwent coronary angiography were included in this study. The Gensini score was used to estimate the severity of coronary vascular lesions. The predictive ability of SIRI for CHD was evaluated using receiver operating characteristic (ROC) curves. Binary multivariate logistic regression analysis was used to predict the likelihood of CHD based on the SIRI index. The results showed that people with higher SIRI were more likely to have CHD (P < 0.001). After controlling for other risk factors, the highest quartile had a significantly higher incidence of coronary artery disease compared to the lowest quartile (odds ratio [OR] 2.25, 95% confidence interval [CI] 1.73-3.92, P < 0.001). Furthermore, the Gensini score was significantly higher in the fourth quartile group (T4) compared to the first (T1) and second (T2) quartile groups (P < 0.001). Additionally, the SIRI was significantly higher in the group with severe coronary artery lesions compared to the mild and moderate groups (P < 0.001). The SIRI also showed a higher predictive ability for the extent of coronary lesions under the ROC curve compared to other commonly used markers, including platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) (P < 0.001). Therefore, SIRI positively correlates with coronary artery stenosis in CHD patients, serving as an effective early screening marker for assessing stenosis severity.
本研究旨在分析全身性炎症反应指数（SIRI）与冠心病（CHD）患者冠状动脉狭窄严重程度之间的相关性，并评估 SIRI 对冠状动脉狭窄严重程度的预测价值。共纳入 2990 例行冠状动脉造影的患者，采用 Gensini 评分评估冠状动脉血管病变严重程度，应用受试者工作特征（ROC）曲线评估 SIRI 对 CHD 的预测能力，采用二元多因素 Logistic 回归分析基于 SIRI 指数预测 CHD 的可能性。结果显示，SIRI 较高的患者更易患 CHD（P<0.001）。在控制其他危险因素后，与最低四分位数相比，SIRI 最高四分位数的冠心病发生率显著升高（比值比[OR]2.25，95%置信区间[CI]1.73-3.92，P<0.001）。此外，第四四分位数组（T4）的 Gensini 评分明显高于第一（T1）和第二（T2）四分位数组（P<0.001）。此外，与轻度和中度冠状动脉病变组相比，严重冠状动脉病变组的 SIRI 明显更高（P<0.001）。与血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）和中性粒细胞与淋巴细胞比值（NLR）等常用标志物相比，SIRI 在 ROC 曲线下对冠状动脉病变程度具有更高的预测能力（P<0.001）。综上所述，SIRI 与 CHD 患者的冠状动脉狭窄呈正相关，是评估狭窄严重程度的有效早期筛查标志物。
